Université Paris Saclay, Faculté de Pharmacie
+33.1.46.83.59.68
ea3544@gmail.com

CESP - Team Moods

Laboratory of Neuropharmacology - Preclinic Unit

TEAM

Meet with our team

RESEARCH

Our current area of research

PUBLICATIONS

Find and read our last publications

Latest News

All the important news from our team

Reviving through human hippocampal newborn neurons

Recent contradictory data has renewed discussion regarding the existence of adult hippocampal neu- rogenesis (AHN) in humans, i.e., the continued production of new neurons in the brain after birth. The present[…]

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Olfactory deficits in major depressive disorders and venlafaxine treatment response

In a collaborative paper with the Perception and Memory Unit at the Institut Pasteur, the Department of Epidemiology and Population Health, American University of Beirut and the Smell and Taste[…]

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Sex-specific neurobiological actions of prophylactic ketamine

To read this week: a paper co-authored by researchers from the MOODS team: the role of sex and ovarian hormones on the effect of certain anti-depressants (Ketamine) in mice. How[…]

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New website

As the title say, we finally took some time to update our website. The work is still on going and we will try to make it fully functionnal in the[…]

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Our Team

Meet our scientific team

Alain
Gardier

Professor, PhD, PharmD

Denis
David

Professor,
PhD

François Coudoré

Professor, PhD, MD, PharmD

Jean-Philippe Guilloux

Assistant Professor, PhD

Laurent Tritschler

Assistant Professor, PhD

Indira
Mendez-David

Research Engineer, PhD 

Céline
Defaix

Technician
PhD

Thi Mai Loan Nguyen

PhD student, PharmD

Rodolphe
Lebeau

PhD
student

Antoine
Coignée

Undergraduate

Louise
Huchard

Technician

Françoise
Huteau

Administrative

A translational team, working in preclinic and with psychiatrists to better understand the underpinnings of anxio-depressive disorders

Our expertise

For the last twenty years, our laboratory gained in expertise in the context of neuropsyghopharmacology

The lab is composed of young scientists with diverse and combinatorial skills in various techniques from molecular biology to animal behavior analysis, microdialysis and electrophysiology


Our research focus on :
• developing comprehensive animal models of mood disorders
• understanding the mechanisms underlying human major depression and other mood disorders
• elucidate the mechanism of action of existing or new pharmacologic antidepressant therapies
Neurochemistry

Our laboratory has gained a strong expertise in in vivo microdialysis to evaluate intracerebral levels of monoamines, GABA and glutamate.

Emotion and cognition behavior

We can monitor emotion-related behavior and cognition using videotracking of animals’ behavior in the Open Field, Novelty Suppressed Feeding, Elevated Plus Maze, Fear Conditioning tests, Morris water maze, Barnes maze and novel object recognition tests.

Immunohistochemistry

Our team is expert in immunohistochemistry in the brain, for instance allowing the monitoring of adult hippocampal neurogenesis.

Optogenetics & Fiber photometry

With the use of these techniques, we can now explorate the molecular and cellular underpinnings of mood disorders and antidepressant response or resistance to treatment.