Professor
PharmD, MD, PhD
Tel: +33(0)1.80.00.63.32
Area of Research
Toxicology, Neuropharmacology and Neurobiology of pain.
Expertise
Behavioral analysis of pain
Research Theme
– In vivo characterization of nociception in animal models of depression by behavioural approaches: loss of functions (muscular weakness, paralysis, areflexia, hypoesthesia…), appearance of “positive” signs primarily represented by painful feelings (spontaneous or chemically induced, hyperalgesia or allodynia) or not painful (paraesthesia, dysesthesia).
– Collaboration with the Drugs and Metabolites Analysis service (SAMM)
Selected Publications
Tutakhail, A., Q. A. Nazari, S. Khabil, A. Gardier and F. Coudore (2019). « Muscular and mitochondrial effects of long-term fluoxetine treatment in mice, combined with physical endurance exercise on treadmill. » Life Sci 232: 116508.
Feng, J., S. Lepetre-Mouelhi, A. Gautier, S. Mura, C. Cailleau, F. Coudore, M. Hamon and P. Couvreur (2019). « A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine. » Sci Adv 5(2): eaau5148.
Tutakhail, A., Q. A. Nazary, D. Lebsir, S. Kerdine-Romer and F. Coudore (2018). « Induction of brain Nrf2-HO-1 pathway and antinociception after different physical training paradigms in mice. » Life Sci 209: 149-156.
Delmotte, J. B., A. Tutakhail, K. Abdallah, P. Reach, M. D’Ussel, G. Deplanque, H. Beaussier and F. Coudore (2018). « Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy. » Neurol Res Int 2018: 1254602.
Delmotte, J. B., H. Beaussier, N. Auzeil, F. Massicot, O. Laprevote, E. Raymond and F. Coudore (2018). « Is quantitative sensory testing helpful in the management of oxaliplatin neuropathy? a two-year clinical study. » Cancer Treat Res Commun 17: 31-36.
Andriamamonjy, M., J. B. Delmotte, F. Savinelli, H. Beaussier and F. Coudore (2017). « Quantification of Chronic Oxaliplatin-Induced Hypesthesia in Two Areas of the Hand. » J Clin Neurophysiol 34(2): 126-131.
Hache, G., B. P. Guiard, T. H. Nguyen, G. Quesseveur, A. M. Gardier, D. Peters, G. Munro and F. Coudore (2015). « Antinociceptive activity of the new triple reuptake inhibitor NS18283 in a mouse model of chemotherapy-induced neuropathic pain. » Eur J Pain 19(3): 322-333.
Massicot, F., G. Hache, L. David, D. Chen, C. Leuxe, L. Garnier-Legrand, P. Rat, O. Laprevote and F. Coudore (2013). « P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and Approach. » PLoS One 8(6): e66830.
Coudore, F., D. Roche, S. Lefeuvre, D. Faussot, E. M. Billaud, M. A. Loriot and P. Beaune (2012). « Validation of an Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometric Method for Quantifying Uracil and 5,6-Dihydrouracil in Human Plasma. » Journal of chromatographic science.
Hache, G., B. P. Guiard, Y. Le Dantec, S. Orvoen, D. J. David, A. M. Gardier and F. Coudore (2012). « Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression. » Neuroreport 23(9): 525-529.
Liotier, J. and F. Coudore (2011). « Drug monitoring of a case of citalopram overdosage. » Drug Chem Toxicol 34(4): 420-423.
Hache, G., F. Coudore, A. M. Gardier and B. Guiard (2011). « Monoaminergic Antidepressants in the Relief of Pain: Potential Therapeutic Utility of Triple Reuptake Inhibitors (TRIs). » Pharmaceuticals 4(2): 285-342.
Gardier, A. M., B. P. Guiard, J. P. Guilloux, C. Reperant, F. Coudore and D. J. David (2009). « Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: a review. » Fundam Clin Pharmacol 23(1): 23-42.
Authier, N., D. Balayssac, F. Marchand, B. Ling, A. Zangarelli, J. Descoeur, F. Coudore, E. Bourinet and A. Eschalier (2009). « Animal models of chemotherapy-evoked painful peripheral neuropathies. » Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 6(4): 620-629.
Ling, B., F. Coudore, L. Decalonne, A. Eschalier and N. Authier (2008). « Comparative antiallodynic activity of morphine, pregabalin and lidocaine in a rat model of neuropathic pain produced by one oxaliplatin injection. » Neuropharmacology 55(5): 724-728.
Deltheil, T., B. P. Guiard, J. P. Guilloux, L. Nicolas, C. Delomenie, C. Reperant, E. Le Maitre, I. Leroux-Nicollet, S. Benmansour, F. Coudore, D. J. David and A. M. Gardier (2008). « Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus. » Pharmacol Biochem Behav 90(2): 174-183.
Ling, B., N. Authier, D. Balayssac, A. Eschalier and F. Coudore (2007). « Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat. » Pain 128(3): 225-234.
Ling, B., M. A. Coudore-Civiale, D. Balayssac, A. Eschalier, F. Coudore and N. Authier (2007). « Behavioral and immunohistological assessment of painful neuropathy induced by a single oxaliplatin injection in the rat. » Toxicology 234(3): 176-184.
Book Chapters
Deltheil, T., B. Guiard, J. P. Guilloux, D. David, F. Coudore and A. M. Gardier (2012). Sérotonine et facteurs neurotrophiques dans la dépression. Sérotonine: aspects biologiques et cliniques. O. Spreux-Varoquaux. Paris, Lavoisier – Médecine Sciences. 1: 329-370.