Denis David

Full Professor in Pharmacology

PhD

Tel:  +33(0)1.80.00.63.40

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Bibliography

https://orcid.org/0000-0002-0506-6688

ResearcherID: K-1173-2014

Scopus Author ID: 16401070300

My bibliography

• 96 publications indexed Pubmed, 2 book chapters, >100 posters, 35 invited presentation, 2 patents.
  •  https://www.ncbi.nlm.nih.gov/myncbi/1d3EdrblyA3At/bibliography/public/
  • H-index Scopus: 43

Area of research

Neuropharmacology, Neurobiology of anxiety/depression, Animal Models of Psychiatric Disorders.

Expertise

Contribution of neurotrophin and hippocampal neurogenesis to pathological states such as depression and anxiety.

Research Theme

After graduating from Paris-Sud XI University for his master, Denis David chose the psychopharmacology department for his PhD at the University of Nantes in France. During this period, he became interested in progression of behavioral pharmacology and how to improve animal model of anxiety/depression to mimic these psychiatric disorders.

To advance his training in neuropsychiatry and learn molecular biology and histology, in 2003, with a grant from the French Pharmaceutical companies association, Denis David chose to pursue a postdoctoral fellowship in Pr René Hen’s laboratory at Columbia University College of Physicians & Surgeons (New York, USA). Pr Hen’s group combines the use of mouse genetics, electrophysiology, and pharmacology to study psychiatric disorders at the level of genes, circuits and behavior. As part of his fellowship, he studied mainly the role of adult hippocampal neurogenesis in the behavioral responses to antidepressant drugs.

He was then recruited as Assistant Professor in Pharmacology in 2004 in the team of Pr Alain Gardier at the University Paris-Sud XI. He pursued the characterization of a new animal model of anxiety/depression, in collaboration with Pr René Hen’s lab using various approaches, such as neurochemical, biochemical and behavioral approaches. Thus, using an ablation strategy of the hippocampal neurogenesis in this new animal model of anxiety/depression, he has shown that hippocampal neurogenesis is required for some of the behavioral effects of antidepressants. Novel antidepressant therapies aimed at targeting directly or not hippocampal neurogenesis are currently under investigation in this new model of anxiety/depression.  

Current funded projects

• Title: Synaptogenesis as a readout of antidepressant response in major depression: a translational approach.
  • Major Goals: The current project proposes a translational program to provide in-depth monitoring of synaptogenesis associated with efficacy of conventional antidepressant treatment with venlafaxine (VENLA) alone or associated with KET as a booster of efficacy.
    • Status of Support: current
    • Project Number: Synaptomood
    • Name of PI: Romain Colle/ Claire Leroy/Denis David/ Nicolas Tournier
    • Co-investigator: Indira Mendez-David, Denis David
    • Source of Support: French National Agency for Research
    • Primary Place of Performance: Universite Paris-Saclay
    • Project/Proposal Start and End Date: (MM/YYYY) (if available): 01/11/22 – 30/10/26
    • Total Award Amount (including Indirect Costs): 795 000€

• Title: Relevance of [¹¹C]UCB-J Positron Emission Tomography imaging to non-invasively monitor the role of synaptic plasticity in relation to antidepressant therapeutic efficacy
  • Major Goals: This proposal is an exploratory preclinical project aiming to profile the in vivo dynamics of changes in synaptic density in response to antidepressant treatment.
    • Status of Support: current
    • Project Number: Graduate School Health and Drug Sciences-2021
    • Name of PI: Denis David/ Indira Mendez-David/Nicolas Tournier/Claire Leroy
    • Source of Support: Platform collaboration call
    • Primary Place of Performance: Universite Paris-Saclay
    • Project/Proposal Start and End Date: 01/01/22 – 31/12/22
    • Total Award Amount (including Indirect Costs): 10 000€

• Title: Serotonin 4 ligands to treat anxiety
  • Major Goals: The current project has the dual objective of fully characterizing the anxiolytic properties of this new class of 5-HT4R agonists and pursuing their optimization to improve their efficacy and selectivity.
    • Status of Support: current
    • Project Number: Healthi-2022
    • Name of PD/PI: Denis David/ Indira Mendez-David/Delphine Joseph/Emmanuelle Drege
    • Source of Support: Emergence call_Interdisciplinary Action Health and Therapeutic Innovation
    • Primary Place of Performance: Universite Paris-Saclay
    • Project/Proposal Start and End Date: 01/09/22 – 31/08/23
    • Total Award Amount (including Indirect Costs): 50 000€

• Title: Role of adult hippocampal neurogenesis in prevention of relapse
  • Major Goals: The major goal of this project is to study the contribution of adult hippocampal neurogenesis to the therapeutic and prophylactic effects of antidepressant medications.
  • Name of PD/PI: Denis David
  • Source of Support: Lundbeck Inc. France
  • Primary Place of Performance: Faculte de Pharmacie, Universite Paris-Saclay
  • Project/Proposal Start and End Date: (MM/YYYY) (if available):, 01/01/18 – 12/31/22
  • Total Award Amount (including Indirect Costs): 105 000€

• Title: Role of neuroglial interactions in the cerebellar control of cognitive functions
  • Major Goals: The major goal of this project is to determine the presence of specific monoamine enzymes and transporters in Bergmann glial cells and their influence on monoamines concentrations.
    • Name of PD/PI: Christelle Rochefort/
    • Co-investigator: Denis David
    • Source of Support: National Agency for Research
    • Primary Place of Performance: Faculte de Pharmacie, Universite Paris-Saclay
    • Project/Proposal Start and End Date: (MM/YYYY) (if available):, 01/01/21 – 12/31/24
    • Total Award Amount (including Indirect Costs): 117 820€

Past funded projects

• Title: Signature biologique périphérique et centrale de la réponse aux ECT
  • Name of PI: Denis David, Raphaël. Gaillard
  • Co-investigator: Jean-Philippe Guilloux
  • Source of Support: Fondation de France
  • Project/Proposal Start and End Date: (MM/YYYY) (if available):   01/01/18–31/12/21
  • Total Award Amount (including Indirect Costs): 198315€

• Title: Prophylactic effects of Ketamine:
  • Name of PI: Denis David, C. Denny (Columbia University)
  • Source of Support: Chateaubriand Fellowship,
  • Project/Proposal Start and End Date: (MM/YYYY) (if available): 01/01/18-01/05/18
  • Total Award Amount (including Indirect Costs): 4 000€

• Title: Role of Huntingtin in depression
  • Name of PI: Sandrine Humbert
  • Co-investigator: Denis David
  • Source of Support: Fédération Recherche Cerveau,
  • Project/Proposal Start and End Date: (MM/YYYY) (if available): 01/01/15-31/12/16
  • Total Award Amount (including Indirect Costs): 22 500€

• Title: Proteomic signature after antidepressant treatment
  • Name of PD/PI: Denis David, Indira David
  • Source of Support: IPSIT, Université Paris-Sud     
  • Project/Proposal Start and End Date: (MM/YYYY) (if available): 01/09/2015-31/08/2016
  • Total Award Amount (including Indirect Costs): 500€

• Title: Role of b-arrestins in antidepressant effects
  • Name of PI: René Hen, Denis DAVID
  • Source of Support: NARSAD YI, Behavior and Brain Research Foundation
  • Project/Proposal Start and End Date: (MM/YYYY) (if available):15/07/11-14/07/13        
  • Total Award Amount (including Indirect Costs): 60 000€

• Title: ANR Neuroscience TRAP-HD
  • Name of PI: Frédéric SAUDOU,
  • Co-investigator: Denis DAVID
  • Source of Support: ANR      
  • Project/Proposal Start and End Date: (MM/YYYY) (if available): 03/02/09-02/02/12
  • Total Award Amount (including Indirect Costs): 100 236€

• Title: Role of adult hippocampal neurogenesis in antidepressant effects
  • Name of PI: Denis DAVID
  • Source of Support: Bonus qualité recherche, Université Paris-Sud
  • Project/Proposal Start and End Date: (MM/YYYY) (if available): 01/01/08-31/12/08
  • Total Award Amount (including Indirect Costs): 20 000€

• Contract for Pharmaceutical companies: 26

Honors

• 2022-2023:     Visiting Professor, Division of Integrative Neurosciences, Dpt of Psychiatry, Columbia University
• 2022                Schaefer Research Scholars Program Awards, Columbia University, USA
• 2020                Appointed to the rank of Professor class 1 from the University National Committee.
• 2015                Award for the best innovation in basic science: CORT model. Deniker Foundation.
• 2014                Award of the best publication in Psychiatry, French Psychiatry meeting.
• Since 2012                 Award for Associate Professor scientific excellence (Universite Paris-Sud.
• 2011-2013      NARSAD Young Investigator Award (The Brain and Behavior Research Foundation, BBRF, USA).
• 2011                Reviewer of the year, Neuropharmacology journal.
• 2008-2009      Research call from University Paris-Sud.
• 2002                French Society of Pharmacology Award.
• 2003-2004      Postdoctoral fellowship from Les Entreprises du Médicament.

Selected Publications

 Colle, R., P. Masson, C. Verstuyft, B. Feve, E. Werner, C. Boursier-Neyret, B. Walther, D. J. David, B. Boniface, B. Falissard, P. Chanson, E. Corruble and L. Becquemont (2019). « Peripheral tryptophan, serotonin, kynurenine and their metabolites in major depression: a case-control study. » Psychiatry Clin Neurosci.

 Chen, B. K., I. Mendez-David, V. M. Luna, C. Faye, A. M. Gardier, D. J. David and C. A. Denny (2019). « Prophylactic efficacy of 5-HT4R agonists against stress. » Neuropsychopharmacology.

 Faye, C., R. Hen, B. P. Guiard, C. A. Denny, A. M. Gardier, I. Mendez-David and D. J. David (2019). « Rapid anxiolytic effects of RS67333, a serotonin type 4 receptor agonist, and diazepam, a benzodiazepine, are mediated by projections from the prefrontal cortex to the dorsal raphe nucleus. » Biol Psychiatry. In Press

 Colle, R., A. E. K. Ait Tayeb, P. Mesdom, M. de Menthon, L. Becquemont, C. Verstuyft, D. J. David, O. Lambotte and E. Corruble (2019). « Methemoglobinemia as a biomarker of dapsone-induced mania severity. » J Affect Disord 254: 122-123.

 Zhang, H., C. Zhang, J. Vincent, D. Zala, C. Benstaali, M. Sainlos, D. Grillo-Bosch, S. Daburon, F. Coussen, Y. Cho, D. J. David, F. Saudou, Y. Humeau and D. Choquet (2018). « Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models. » Nat Commun 9(1): 4272.

 Deflesselle, E., R. Colle, L. Rigal, D. J. David, A. Vievard, S. Martin, L. Becquemont, C. Verstuyft and E. Corruble (2018). « The TRKB rs2289656 genetic polymorphism is associated with acute suicide attempts in depressed patients: A transversal case control study. » PLoS One 13(10): e0205648.

 Felice, D., J. P. Guilloux, A. Pehrson, Y. Li, I. Mendez-David, A. M. Gardier, C. Sanchez and D. J. David (2018). « Vortioxetine Improves Context Discrimination in Mice Through a Neurogenesis Independent Mechanism. » Front Pharmacol 9: 204.

 Colle, R., F. Boichot, E. Bouteiller, C. Elie-Lefebvre, P. Hardy, D. J. David, C. Verstuyft and E. Corruble (2018). « Restless Legs Syndrome and Schizophrenia: A Case Report. » J Clin Psychopharmacol 38(1): 91-92.

 Tritschler, L., M. A. Kheirbek, Y. L. Dantec, I. Mendez-David, J. P. Guilloux, C. Faye, J. Doan, T. H. Pham, R. Hen, D. J. David and A. M. Gardier (2017). « Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens. » Neurosci Res.

 Pham, T. H., C. Defaix, X. Xu, S. X. Deng, N. Fabresse, J. C. Alvarez, D. W. Landry, R. A. Brachman, C. A. Denny and A. M. Gardier (2017). « Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects. » Biol Psychiatry.

 Petit, A. C., K. El Asmar, D. J. David, A. M. Gardier, L. Becquemont, B. Feve, C. Verstuyft and E. Corruble (2018). « The association of beta-arrestin2 polymorphisms with response to antidepressant treatment in depressed patients. » Prog Neuropsychopharmacol Biol Psychiatry 81: 74-79.

 Mendez-David, I., C. Boursier, V. Domergue, R. Colle, B. Falissard, E. Corruble, A. M. Gardier, J. P. Guilloux and D. J. David (2017). « Differential Peripheral Proteomic Biosignature of Fluoxetine Response in a Mouse Model of Anxiety/Depression. » Front Cell Neurosci 11: 237. 

 Faye, C., J. C. McGowan, C. A. Denny and D. J. David (2017). « Neurobiological mechanisms of stress resilience and implications for the aged population. » Curr Neuropharmacol.

 Mendez-David, I., J. P. Guilloux, M. Papp, L. Tritschler, E. Mocaer, A. M. Gardier, S. Bretin and D. J. David (2017). « S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms. » Front Pharmacol 8: 462.

 Colle, R., S. Trabado, D. J. David, S. Brailly-Tabard, P. Hardy, B. Falissard, B. Feve, L. Becquemont, C. Verstuyft and E. Corruble (2017). « Plasma BDNF Level in Major Depression: Biomarker of the Val66Met BDNF Polymorphism and of the Clinical Course in Met Carrier Patients. » Neuropsychobiology 75(1): 39-45.

 Guilloux, J. P., A. M. Gardier and D. J. David (2017). « New targets and modalities of antidepressant drugs development. » La lettre du Pharmacologue 31(1): 12-18.

 Lugert, S., T. Kremer, R. Jagasia, A. Herrmann, S. Aigner, C. Giachino, I. Mendez-David, A. M. Gardier, J. P. Carralot, H. Meistermann, A. Augustin, M. D. Saxe, J. Lamerz, G. Duran-Pacheco, A. Ducret, V. Taylor, D. J. David and C. Czech (2017). « Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis. » Sci Rep 7: 46543.

 Deflesselle, E., C. Verstuyft, A. C. Petit, P. Hardy, D. J. David, B. Falissard, B. Feve, L. Rigal, L. Becquemont, E. Corruble and R. Colle (2017). « No impact of eight NTRK2 genetic polymorphisms on 6-month antidepressant efficacy in depressed patients. » Pharmacogenomics 18(4): 349-357.

 Mekiri, M., A. M. Gardier, D. J. David and J. P. Guilloux (2017). « Chronic corticosterone administration effects on behavioral emotionality in female c57bl6 mice. » Exp Clin Psychopharmacol 25(2): 94-104.

 Guilloux, J. P., B. A. Samuels, I. Mendez-David, A. Hu, M. Levinstein, C. Faye, M. Mekiri, E. Mocaer, A. M. Gardier, R. Hen, A. Sors and D. J. David (2017). « S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. » Sci Rep 7: 42946.

 Pham, T. H., I. Mendez-David, C. Defaix, B. P. Guiard, L. Tritschler, D. J. David and A. M. Gardier (2017). « Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB/cJ mice. » Neuropharmacology 112(Pt A): 198-209.

 David, D. J. and D. Gourion (2016). « [Antidepressant and tolerance: Determinants and management of major side effects]. » Encephale 42(6): 553-561.

 Corvol, J. C., S. Goni, R. Bordet and R. T. N. participants of the Giens Xxxi (2016). « Translational research on cognitive and behavioural disorders in neurological and psychiatric diseases. » Therapie 71(1): 1-13, 15-26.

 Nautiyal, K. M., L. Tritschler, S. E. Ahmari, D. J. David, A. M. Gardier and R. Hen (2016). « A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors. » Neuropsychopharmacology 41(12): 2941-2950.

 David, D. J. and A. M. Gardier (2016). « [The pharmacological basis of the serotonin system: Application to antidepressant response]. » Encephale 42(3): 255-263.

 David D. J., L. Tritschler, J. P. Guilloux, A. M. Gardier, C. Sanchez, R. Gaillard (2016). « Pharmacological properties of vortioxetine and its pre-clinical consequences. » Encéphale. 42: 1S12

 Darcet, F., A. M. Gardier, R. Gaillard, D. J. David and J. P. Guilloux (2016). « Cognitive Dysfunction in Major Depressive Disorder. A Translational Review in Animal Models of the Disease. » Pharmaceuticals (Basel) 9(1).

 Darcet, F., A. M. Gardier, D. J. David and J. P. Guilloux (2016). « Chronic 5-HT receptor agonist treatment restores learning and memory deficits in a neuroendocrine mouse model of anxiety/depression. » Neurosci Lett 616: 197-203.

 Samuels, B. A., I. Mendez-David, C. Faye, S. A. David, K. A. Pierz, A. M. Gardier, R. Hen and D. J. David (2016). « Serotonin 1A and Serotonin 4 Receptors: Essential Mediators of the Neurogenic and Behavioral Actions of Antidepressants. » Neuroscientist 22(1): 26-45.

 Quesseveur, G., A. C. Petit, H. T. Nguyen, L. Dahan, R. Colle, S. Rotenberg, I. Seif, P. Robert, D. David, J. P. Guilloux, A. M. Gardier, C. Verstuyft, L. Becquemont, E. Corruble and B. P. Guiard (2016). « Genetic dysfunction of serotonin 2A receptor hampers response to antidepressant drugs: A translational approach. » Neuropharmacology 105: 142-153.

 Schloesser, R. J., S. Orvoen, D. V. Jimenez, N. F. Hardy, K. R. Maynard, M. Sukumar, H. K. Manji, A. M. Gardier, D. J. David and K. Martinowich (2015). « Antidepressant-like Effects of Electroconvulsive Seizures Require Adult Neurogenesis in a Neuroendocrine Model of Depression. » Brain Stimul 8(5): 862-867.

 Colle, R., E. Deflesselle, S. Martin, D. J. David, P. Hardy, A. Taranu, B. Falissard, C. Verstuyft and E. Corruble (2015). « BDNF/TRKB/P75NTR polymorphisms and their consequences on antidepressant efficacy in depressed patients. » Pharmacogenomics 16(9): 997-1013.

 Felice, D., O. F. O’Leary, J. F. Cryan, T. G. Dinan, A. M. Gardier, C. Sanchez and D. J. David (2015). « When ageing meets the blues: Are current antidepressants effective in depressed aged patients? » Neurosci Biobehav Rev 55: 478-497.

 Brachman, R. A., J. C. MCGowan, J. N. Perusini, S. C. Lim, T. H. Pham, C. Faye, A. M. Gardier, I. Mendez-David, D. J. David, R. Hen and C. A. Denny (2015). « Ketamine as a prophylactic against stress-induced depressive-like behavior. » Biological Psychiatry In Press.

 Nautiyal, K. M., K. F. Tanaka, M. M. Barr, L. Tritschler, Y. Le Dantec, D. J. David, A. M. Gardier, C. Blanco, R. Hen and S. E. Ahmari (2015). « Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity. » Neuron 86(3): 813-826.

 Mendez-David, I., L. Tritschler, Z. E. Ali, M. H. Damiens, M. Pallardy, D. J. David, S. Kerdine-Romer and A. M. Gardier (2015). « Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression. » Neurosci Lett 597: 121-126.

 Tritschler, L., D. Felice, R. Colle, J. P. Guilloux, E. Corruble, A. M. Gardier and D. J. David (2014). « Vortioxetine for the treatment of major depressive disorder. » Expert Rev Clin Pharmacol: 1-15.

 Le Dantec, Y., G. Hache, J. P. Guilloux, B. P. Guiard, D. J. David, J. Adrien and P. Escourrou (2014). « NREM sleep hypersomnia and reduced sleep/wake continuity in a neuroendocrine mouse model of anxiety/depression based on chronic corticosterone administration. » Neuroscience 274: 357-368..

 Darcet, F., I. Mendez-David, L. Tritschler, A. M. Gardier, J. P. Guilloux and D. J. David (2014). « Learning and memory impairments in a neuroendocrine mouse model of anxiety/depression. » Front Behav Neurosci 8: 136.

 Pla, P., S. Orvoen, F. Saudou, D. J. David and S. Humbert (2014). « Mood disorders in Huntington’s disease: from behavior to cellular and molecular mechanisms. » Front Behav Neurosci 8: 135.

 Petit, A. C., G. Quesseveur, F. Gressier, R. Colle, D. J. David, A. M. Gardier, F. Ferreri, J. P. Lepine, B. Falissard, C. Verstuyft, B. P. Guiard and E. Corruble (2014). « Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder. » Prog Neuropsychopharmacol Biol Psychiatry 54: 76-82.

 Mendez-David, I., D. J. David, F. Darcet, M. V. Wu, S. Kerdine-Romer, A. M. Gardier and R. Hen (2014). « Rapid Anxiolytic Effects of a 5-HT Receptor Agonist Are Mediated by a Neurogenesis-Independent Mechanism. » Neuropsychopharmacology. In Press

 Mendez-David, I., Z. El-Ali, R. Hen, B. Falissard, E. Corruble, A. M. Gardier, S. Kerdine-Romer and D. J. David (2013). « A method for biomarker measurements in peripheral blood mononuclear cells isolated from anxious and depressed mice: beta-arrestin 1 protein levels in depression and treatment. » Front Pharmacol 4: 124.

 Pla, P., S. Orvoen, C. Benstaali, S. Dodier, A. M. Gardier, D. J. David, S. Humbert and F. Saudou (2013). « Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse. » PLoS One 8(9): e73902.

 Guilloux, J. P., I. Mendez-David, A. Pehrson, B. P. Guiard, C. Reperant, S. Orvoen, A. M. Gardier, R. Hen, B. Ebert, S. Miller, C. Sanchez and D. J. David (2013). « Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. » Neuropharmacology 73: 147-159.

 Nguyen, H. T., B. P. Guiard, A. Bacq, D. J. David, I. David, G. Quesseveur, S. Gautron, C. Sanchez and A. M. Gardier (2013). « Blockade of the high-affinity noradrenaline transporter (NET) by the selective 5-HT reuptake inhibitor escitalopram: an in vivo microdialysis study in mice. » Br J Pharmacol 168(1): 103-116.

 Quesseveur, G., C. Reperant, D. J. David, A. M. Gardier, C. Sanchez and B. P. Guiard (2013). « 5-HT(2)A receptor inactivation potentiates the acute antidepressant-like activity of escitalopram: involvement of the noradrenergic system. » Exp Brain Res 226(2): 285-295.

 Quesseveur, G., D. J. David, M. C. Gaillard, P. Pla, M. V. Wu, H. T. Nguyen, V. Nicolas, G. Auregan, I. David, A. Dranovsky, P. Hantraye, R. Hen, A. M. Gardier, N. Deglon and B. P. Guiard (2013). « BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities. » Transl Psychiatry 3: e253.

 Mendez-David, I., R. Hen, A. M. Gardier and D. J. David (2013). « Adult hippocampal neurogenesis: an actor in the antidepressant-like action. » Ann Pharm Fr 71(3): 143-149.

 Ben M’Barek, K., P. Pla, S. Orvoen, C. Benstaali, J. D. Godin, A. M. Gardier, F. Saudou, D. J. David and S. Humbert (2013). « Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis. » J Neurosci 33(20): 8608-8620..

 David, D. J. (2013). « Mécanisme d’action des antidépresseurs : nouvelles approches. » Encephale 38 Suppl 2: S45-48.

 Quesseveur, G., C. Reperant, D. J. David, A. M. Gardier, C. Sanchez and B. P. Guiard (2013). « 5-HT(2)A receptor inactivation potentiates the acute antidepressant-like activity of escitalopram: involvement of the noradrenergic system. » Exp Brain Res 226(2): 285-295.

 Xia, L., C. Delomenie, I. David, Q. Rainer, M. Marouard, H. Delacroix, D. J. David, A. M. Gardier and J. P. Guilloux (2012). « Ventral hippocampal molecular pathways and impaired neurogenesis associated with 5-HT(1)A and 5-HT(1)B receptors disruption in mice. » Neuroscience letters 521(1): 20-25.

 Hache, G., B. P. Guiard, Y. Le Dantec, S. Orvoen, D. J. David, A. M. Gardier and F. Coudore (2012). « Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression. » Neuroreport 23(9): 525-529.

 Nguyen, H. T., B. P. Guiard, A. Bacq, D. J. David, I. David, G. Quesseveur, S. Gautron, C. Sanchez and A. M. Gardier (2013). « Blockade of the high-affinity noradrenaline transporter (NET) by the selective 5-HT reuptake inhibitor escitalopram: an in vivo microdialysis study in mice. » Br J Pharmacol 168(1): 103-116.

 Rainer, Q., H. T. Nguyen, G. Quesseveur, A. M. Gardier, D. J. David and B. P. Guiard (2012). « Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration. » Molecular pharmacology 81(2): 106-112.

 Samuels, B. A., E. D. Leonardo, R. Gadient, A. Williams, J. Zhou, D. J. David, A. M. Gardier, E. H. Wong and R. Hen (2011). « Modeling treatment-resistant depression. » Neuropharmacology 61(3): 408-413.

 Richardson-Jones, J. W., C. P. Craige, T. H. Nguyen, H. F. Kung, A. M. Gardier, A. Dranovsky, D. J. David, B. P. Guiard, S. G. Beck, R. Hen and E. D. Leonardo (2011). « Serotonin-1A Autoreceptors Are Necessary and Sufficient for the Normal Formation of Circuits Underlying Innate Anxiety. » J Neurosci 31(16): 6008-6018.

 Guilloux, J. P., D. J. David, L. Xia, H. T. Nguyen, Q. Rainer, B. P. Guiard, C. Reperant, T. Deltheil, M. Toth, R. Hen and A. M. Gardier (2011). « Characterization of 5-HT(1A/1B)-/- mice: an animal model sensitive to anxiolytic treatments. » Neuropharmacology 61(3): 478-488.

 Rainer, Q., L. Xia, J. P. Guilloux, C. Gabriel, E. Mocaer, R. Hen, E. Enhamre, A. M. Gardier and D. J. David (2011). « Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety. » Int J Neuropsychopharmacol: 1-15.

 David, D. J., J. Wang, B. A. Samuels, Q. Rainer, I. David, A. M. Gardier and R. Hen (2010). « Implications of the functional integration of adult-born hippocampal neurons in anxiety-depression disorders. » Neuroscientist 16(5): 578-591.

 David, D.J., Samuels, B., Rainer, Q., Wang, J., Marsteller, D., Mendez, I., Drew, M., Craig, D., Guiard, B., Guilloux, J-P., Artymyshyn, R., Gardier, A., Gerald, C., Antonijevic, I., Leonardo, E., Hen, R. (2009) Behavioral effects of fluoxetine in an animal model of anxiety/depression are mediated by both neurogenesis-dependent and independent mechanisms. Neuron, 62, 1-15.

 Rainer, Q., Gardier, A.M., Hen, R,. David, D.J. (2009). Neurogenesis-dependent and independent effects of anti-depressant drugs. Med Sci (Paris)., 25(10):795-8.

 Wang, J., David, D.J., Monckton, J., Battaglia, F., Hen, R. (2008). « Stimulation of maturation and synaptic plasticity of adult-born hippocampal neurons by fluoxetine contributes to the delayed onset of its antidepressant action ». J Neurosci. ,6;28(6):1374-84.

 Deltheil, T., Tanaka, K., Reperant, C., Hen, R., David, D.J., Gardier, A.M. (2009). Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice. Int J Neuropsychopharmacol., 23:1-11.

 David, D.J., Klemenhagen, K.C., Holick, K.A., Saxe, M.D., Mendez I., Santarelli L., Craig, D.A., Swanson, C., Hedge, L.G., Ping, X.L., Dong, D., Marzabadi, M., Gerald, C., Hen, R. (2007). “Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis.” J Pharmacol Exp Ther., Jan 19 321(1):237-48.

 Wang, J. W., D. J. David, J. E. Monckton, F. Battaglia and R. Hen (2008). « Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. » J Neurosci 28(6): 1374-1384.

 Saxe, M. D., F. Battaglia, J. W. Wang, G. Malleret, D. J. David, J. E. Monckton, A. D. Garcia, M. V. Sofroniew, E. R. Kandel, L. Santarelli, R. Hen and M. R. Drew (2006). « Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. » Proc Natl Acad Sci U S A 103(46): 17501-17506.

 Klemenhagen, K. C., J. A. Gordon, D. J. David, R. Hen and C. T. Gross (2006). « Increased fear response to contextual cues in mice lacking the 5-HT1A receptor. » Neuropsychopharmacology 31(1): 101-111.

   Book Chapters

 Mendez-David, I., D. J. David, J.-P. Guilloux, R. Hen and A. M. Gardier (2015). « 5-HT4 Receptor Subtype, β-Arrestin Level, and Rapid-Onset Effects of Antidepressant Drugs. »  95: 101-121.

 Samuels, B., I. David, D. J. David, A. M. Gardier and R. Hen (2014). Role of hippocampal neurogenesis in the mechanism of action of antidepressant/anxiolytic drugs in animal model of depression and anxiety. Neurobiology of mood disorders. B. P. Guiard and E. Dremencov, Bentham Science Publishers: 210-233.

 David, D. J., B. P. Guiard, J. P. Guilloux and A. M. Gardier (2013). Pharmacologie des antidépresseurs : modèles animaux. Les Antidépresseurs. E. Corruble. Paris, Flammarion Médecine/Sciences: 40-51.

 Guilloux, J. P., D. J. David, B. A. Samuels, I. David, A. M. Gardier and B. P. Guiard (2012). Non-response to initial antidepressant therapy. Psychology. Rijeka, Croatia, InTech.

 Guilloux, J. P., D. J. David, B. A. Samuels, I. David, A. M. Gardier and B. P. Guiard (2012). Non-response to initial antidepressant therapy. Psychology. Rijeka, Croatia, InTech.

 Deltheil, T., B. Guiard, J. P. Guilloux, D. David, F. Coudore and A. M. Gardier (2012). Sérotonine et facteurs neurotrophiques dans la dépression. Sérotonine: aspects biologiques et cliniques. O. Spreux-Varoquaux. Paris, Lavoisier – Médecine Sciences. 1: 329-370.