Université Paris Saclay, Bâtiment Henri Moissan
+33 (0)1.80.00.63.37
ea3544@gmail.com

Abdulkarim Tutakhail

Assistant Professor in Pharmacology

PhD

Tel:  +33(0)1.80.00.63.33

Area of research

Toxicology, Neuropharmacology and Neurobiology of pain.

Expertise

Behavioral analysis of pain

Research Theme

– In vivo characterization of nociception in animal models of depression by behavioural approaches: loss of functions (muscular weakness, paralysis, areflexia, hypoesthesia…), appearance of “positive” signs primarily represented by painful feelings (spontaneous or chemically induced, hyperalgesia or allodynia) or not painful (paraesthesia, dysesthesia).

– Collaboration with the Drugs and Metabolites Analysis service (SAMM)

Selected Publications

Tutakhail, A., Q. A. Nazari, S. Khabil, A. Gardier and F. Coudore (2019). « Muscular and mitochondrial effects of long-term fluoxetine treatment in mice, combined with physical endurance exercise on treadmill. » Life Sci 232: 116508.

Feng, J., S. Lepetre-Mouelhi, A. Gautier, S. Mura, C. Cailleau, F. Coudore, M. Hamon and P. Couvreur (2019). « A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine. » Sci Adv 5(2): eaau5148.

Tutakhail, A., Q. A. Nazary, D. Lebsir, S. Kerdine-Romer and F. Coudore (2018). « Induction of brain Nrf2-HO-1 pathway and antinociception after different physical training paradigms in mice. » Life Sci 209: 149-156.

Delmotte, J. B., A. Tutakhail, K. Abdallah, P. Reach, M. D’Ussel, G. Deplanque, H. Beaussier and F. Coudore (2018). « Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy. » Neurol Res Int 2018: 1254602.