Yann Pelloux

Junior Professor in Pharmacology

PhD

Tel: +33(0)1.80.00.63.29

Area of research

Neuropharmacology, Neurobiology of addiction and emotional behavior, Animal Models of Psychiatric Disorders.

Expertise

Neuropsychological substrate of mental disorders with a particular emphasize on addictive disorders with recently a broader approach on physiological and pathological decision making

Research Theme

Dr Yann Pelloux graduated in 2003 in the laboratory of experimental neuropsychopharmacology at the university of Rouen under the supervision of professor Jean Costentin and doctor Dominique Duterte-Boucher investigating the role of various behavioural traits in the predisposition to use drugs in rodents. He then moved to Cambridge in the United Kingdom for a first post doc in the department of experimental psychology under the supervision of professor Barry Everitt working on the neuropsychological substrate of compulsive cocaine seeking. He then moved to the Bagamore laboratory of the institute of Neuroscience of La Timone in Marseille under the supervision of the doctor Christelle Baunez looking at the pertinence of targeting the subthalamic nucleus for the application of deep brain stimulation in the treatment of addictive disorders. Having been granted a NIDA/INSERM fellowship he moved to the national institute on drug abuse in Baltimore in the United States under the supervision of Yavin Shaham working on the neural basis of relapse to cocaine seeking and then moved in the Adam Mar’s lab at the department of neuroscience and physiology at the Langone center of New York University, investigating the role of cholinergic transmission in various mental disorders. Then granted a Marie Curie fellowship, he moved to the neuromodulation of cortical and subcortical systems laboratory of doctor Raffaella Tonini in Genoa Italy working on the role of serotoninergic transmission in decision making under uncertainty. He recently joined the CESP Mood where is currently working on the decision-making alteration in depressive disorders and its underlying brain mechanisms. He is using viral, genetic and pharmacological and electrical tools combined with parametric and rigorous behavioural manipulations and analysis to monitor or manipulate neural circuit activity and uncover the neural circuit dynamics responsible for making decision. He is collaborating with the different members of the lab to improve treatments against depressive disorders and prevent relapse through multidisciplinary and translational approach, from molecule to complex behaviour and from bench to bedside.

Selected Publications

Giorla, E., S. Nordmann, C. Vielle, Y. Pelloux, P. Roux, C. Protopopescu, C. Manrique, K. Davranche, C. Montanari, L. Giorgi, A. Vilotitch, P. Huguet, P. Carrieri and C. Baunez (2022). « Peer presence and familiarity as key factors to reduce cocaine intake in both rats and humans: an effect mediated by the subthalamic nucleus. » Psychopharmacology (Berl) 239(4): 1097-1113.

Vielle, C., C. Montanari, Y. Pelloux and C. Baunez (2021). « Evidence for a vocal signature in the rat and its reinforcing effects: a key role for the subthalamic nucleus. » Proc Biol Sci 288(1965): 20212260.

Degoulet, M., A. Tiran-Cappello, E. Combrisson, C. Baunez and Y. Pelloux (2021). « Subthalamic low-frequency oscillations predict vulnerability to cocaine addiction. » Proc Natl Acad Sci U S A 118(14).
Boender, A. J., L. Bontempi, L. Nava, Y. Pelloux and R. Tonini (2021). « Striatal Astrocytes Shape Behavioral Flexibility via Regulation of the Glutamate Transporter EAAT2. » Biol Psychiatry 89(11): 1045-1057.

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Breysse, E., J. Meffre, Y. Pelloux, C. A. Winstanley and C. Baunez (2021). « Decreased risk-taking and loss-chasing after subthalamic nucleus lesion in rats. » Eur J Neurosci 53(7): 2362-2375.
Pelloux, Y., E. Giorla, C. Montanari and C. Baunez (2019). « Social modulation of drug use and drug addiction. » Neuropharmacology 159: 107545.

Montanari, C., E. Giorla, Y. Pelloux and C. Baunez (2020). « Subthalamic nucleus mediates the modulation on cocaine self-administration induced by ultrasonic vocalization playback in rats. » Addict Biol 25(1): e12710.

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Pelloux, Y., M. Degoulet, A. Tiran-Cappello, C. Cohen, S. Lardeux, O. George, G. F. Koob, S. H. Ahmed and C. Baunez (2018). « Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use. » Mol Psychiatry 23(12): 2266-2276.

Marchant, N. J., E. J. Campbell, Y. Pelloux, J. M. Bossert and Y. Shaham (2019). « Context-induced relapse after extinction versus punishment: similarities and differences. » Psychopharmacology (Berl) 236(1): 439-448.

Pelloux, Y., A. Minier-Toribio, J. K. Hoots, J. M. Bossert and Y. Shaham (2018). « Opposite Effects of Basolateral Amygdala Inactivation on Context-Induced Relapse to Cocaine Seeking after Extinction versus Punishment. » J Neurosci 38(1): 51-59.

Pelloux, Y., J. K. Hoots, C. Cifani, S. Adhikary, J. Martin, A. Minier-Toribio, J. M. Bossert and Y. Shaham (2018). « Context-induced relapse to cocaine seeking after punishment-imposed abstinence is associated with activation of cortical and subcortical brain regions. » Addict Biol 23(2): 699-712.

Pelloux, Y. and C. Baunez (2017). « Targeting the subthalamic nucleus in a preclinical model of alcohol use disorder. » Psychopharmacology (Berl) 234(14): 2127-2137.

Breysse, E., Y. Pelloux and C. Baunez (2015). « The Good and Bad Differentially Encoded within the Subthalamic Nucleus in Rats(1,2,3). » eNeuro 2(5).

Pelloux, Y. and C. Baunez (2015). « [Surgical strategy to rescue the addicts]. » Med Sci (Paris) 31(6-7): 674-679.

Pelloux, Y., J. Costentin and D. Duterte-Boucher (2015). « Differential involvement of anxiety and novelty preference levels on oral ethanol consumption in rats. » Psychopharmacology (Berl) 232(15): 2711-2721.

Pelloux, Y., J. Meffre, E. Giorla and C. Baunez (2014). « The subthalamic nucleus keeps you high on emotion: behavioral consequences of its inactivation. » Front Behav Neurosci 8: 414.

Pelloux, Y., J. E. Murray and B. J. Everitt (2015). « Differential vulnerability to the punishment of cocaine related behaviours: effects of locus of punishment, cocaine taking history and alternative reinforcer availability. » Psychopharmacology (Berl) 232(1): 125-134.

Murray, J. E., R. Dilleen, Y. Pelloux, D. Economidou, J. W. Dalley, D. Belin and B. J. Everitt (2014). « Increased impulsivity retards the transition to dorsolateral striatal dopamine control of cocaine seeking. » Biol Psychiatry 76(1): 15-22.

Nougaret, S., J. Meffre, Y. Duclos, E. Breysse and Y. Pelloux (2013). « First evidence of a hyperdirect prefrontal pathway in the primate: precise organization for new insights on subthalamic nucleus functions. » Front Comput Neurosci 7: 135.

Coura, R. S., A. Cressant, J. Xia, F. de Chaumont, J. C. Olivo-Marin, Y. Pelloux, J. W. Dalley and S. Granon (2013). « Nonaggressive and adapted social cognition is controlled by the interplay between noradrenergic and nicotinic receptor mechanisms in the prefrontal cortex. » FASEB J 27(11): 4343-4354.

Pelloux, Y., J. E. Murray and B. J. Everitt (2013). « Differential roles of the prefrontal cortical subregions and basolateral amygdala in compulsive cocaine seeking and relapse after voluntary abstinence in rats. » Eur J Neurosci 38(7): 3018-3026.

Besson, M., Y. Pelloux, R. Dilleen, D. E. Theobald, A. Lyon, A. Belin-Rauscent, T. W. Robbins, J. W. Dalley, B. J. Everitt and D. Belin (2013). « Cocaine modulation of frontostriatal expression of Zif268, D2, and 5-HT2c receptors in high and low impulsive rats. » Neuropsychopharmacology 38(10): 1963-1973.

Pelloux, Y. and C. Baunez (2013). « Deep brain stimulation for addiction: why the subthalamic nucleus should be favored. » Curr Opin Neurobiol 23(4): 713-720.

Pelloux, Y., R. Dilleen, D. Economidou, D. Theobald and B. J. Everitt (2012). « Reduced forebrain serotonin transmission is causally involved in the development of compulsive cocaine seeking in rats. » Neuropsychopharmacology 37(11): 2505-2514.

Jonkman, S., Y. Pelloux and B. J. Everitt (2012). « Differential roles of the dorsolateral and midlateral striatum in punished cocaine seeking. » J Neurosci 32(13): 4645-4650.

Jonkman, S., Y. Pelloux and B. J. Everitt (2012). « Drug intake is sufficient, but conditioning is not necessary for the emergence of compulsive cocaine seeking after extended self-administration. » Neuropsychopharmacology 37(7): 1612-1619.

Dilleen, R., Y. Pelloux, A. C. Mar, A. Molander, T. W. Robbins, B. J. Everitt, J. W. Dalley and D. Belin (2012). « High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats. » Psychopharmacology (Berl) 222(1): 89-97.

Economidou, D., Y. Pelloux, T. W. Robbins, J. W. Dalley and B. J. Everitt (2009). « High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence. » Biol Psychiatry 65(10): 851-856.
Pelloux, Y., J. Costentin and D. Duterte-Boucher (2009). « Anxiety increases the place conditioning induced by cocaine in rats. » Behav Brain Res 197(2): 311-316.

Everitt, B. J., D. Belin, D. Economidou, Y. Pelloux, J. W. Dalley and T. W. Robbins (2008). « Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. » Philos Trans R Soc Lond B Biol Sci 363(1507): 3125-3135.

Everitt, B. J., D. M. Hutcheson, K. D. Ersche, Y. Pelloux, J. W. Dalley and T. W. Robbins (2007). « The orbital prefrontal cortex and drug addiction in laboratory animals and humans. » Ann N Y Acad Sci 1121: 576-597.

Pelloux, Y., B. J. Everitt and A. Dickinson (2007). « Compulsive drug seeking by rats under punishment: effects of drug taking history. » Psychopharmacology (Berl) 194(1): 127-137.

Pelloux, Y., J. Costentin and D. Duterte-Boucher (2006). « Novelty preference predicts place preference conditioning to morphine and its oral consumption in rats. » Pharmacol Biochem Behav 84(1): 43-50.
Vautrin, S., Y. Pelloux and J. Costentin (2005). « Preference for caffeine appears earlier in non-anxious than in anxious mice. » Neurosci Lett 386(2): 94-98.

Pelloux, Y., G. Hagues, J. Costentin and D. Duterte-Boucher (2005). « Helplessness in the tail suspension test is associated with an increase in ethanol intake and its rewarding effect in female mice. » Alcohol Clin Exp Res 29(3): 378-388.

Pelloux, Y., J. Costentin and D. Duterte-Boucher (2004). « Differential effects of novelty exposure on place preference conditioning to amphetamine and its oral consumption. » Psychopharmacology (Berl) 171(3): 277-285.