Assistant Professor
PhD
Tel: +33(0)1.80.00.63.36
Area of Research
Neuropharmacology, Neurobiology of anxiety/depression, Animal Models of Psychiatric Disorders.
Expertise
Dr. Tritschler continues now to work in vivo, he is studying the effects of the activation level of the hippocampus on the depressive-like behaviour as well as the changes induced by this stimulation on the hippocampus related brain areas.
Research Theme
Before to join the laboratory, Dr. Tritschler performed a 3 years Postdoctoral position at the Department of Neurology at the Mannheim University Hospital, Germany Directed by Pr. S. Meairs. This has followed a 18-month stay at the ISTEM laboratory in Evry, France Directed by Dr. S. Onteniente, and a 18-month stay in the industry at sanofi-aventis, Vitry-sur-Seine, France, at the Department of neurodegenerative disease, directed by Drs. Duverger and Debeir. Dr. Tritschler completed his PhD thesis at the Laboratory of Neurobiology of Rhythms, Strasbourg, France.
Dr. Tritschler was always interested in topics related to the physiology or physio-pathology and involving in vivo studies.
During his PhD formation, he worked on the understanding of the circadian clock organisation by using two outputs of the clock: the melatonin and the corticosterone rhythms. For the following post-doctoral positions:
-First, he developed and characterised a spinal cord injury model in the rat
-Second, he worked on the relations between the graft and the host in the case of human stem cells graft in a rat model of striatal ischemia
-Third, he studied the effects of mesenchymal stem cells conditioned medium on a rat model of the stroke.
Selected Publications
Nguyen, T. M. L., F. Jollant, L. Tritschler, R. Colle, E. Corruble and A. M. Gardier (2024). « [Ketamine and suicidal behavior: Contribution of animal models of aggression-impulsivity to understanding its mechanism of action]. » Ann Pharm Fr 82(1): 3-14.
Nguyen, T. M. L., F. Jollant, L. Tritschler, R. Colle, E. Corruble and A. M. Gardier (2023). « Pharmacological Mechanism of Ketamine in Suicidal Behavior Based on Animal Models of Aggressiveness and Impulsivity: A Narrative Review. » Pharmaceuticals (Basel) 16(4).
Nguyen, T. M. L., C. Defaix, I. Mendez-David, L. Tritschler, I. Etting, J. C. Alvarez, W. Choucha, R. Colle, E. Corruble, D. J. David and A. M. Gardier (2023). « Intranasal (R, S)-ketamine delivery induces sustained antidepressant effects associated with changes in cortical balance of excitatory/inhibitory synaptic activity. » Neuropharmacology 225: 109357.
Doan, J., C. Defaix, I. Mendez-David, A. M. Gardier, R. Colle, E. Corruble, J. C. McGowan, D. J. David, J. P. Guilloux and L. Tritschler (2023). « Intrahippocampal injection of a selective blocker of NMDA receptors containing the GluN2B subunit, Ro25-6981, increases glutamate neurotransmission and induces antidepressant-like effects. » Fundam Clin Pharmacol.
Mendez-David, I., R. Schofield, L. Tritschler, R. Colle, J. P. Guilloux, A. M. Gardier, E. Corruble, R. Hen and D. J. David (2022). « Reviving through human hippocampal newborn neurons. » Encephale 48(2): 179-187.
Pham, T. H., C. Defaix, T. M. L. Nguyen, I. Mendez-David, L. Tritschler, D. J. David and A. M. Gardier (2020). « Cortical and raphe GABAA, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine. » Pharmacol Biochem Behav 192: 172913.
Doan, J., A. M. Gardier and L. Tritschler (2019). « Role of adult-born granule cells in the hippocampal functions: Focus on the GluN2B-containing NMDA receptors. » Eur Neuropsychopharmacol. In press.
Defaix C., A. Solgadi, T. H. Pham, A. M. Gardier, P. Chaminade, L. Tritschler (2018). Rapid analysis of glutamate, glutamine and GABA in mice frontal cortex microdialysis samples using HPLC coupled to electrospray tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis.
Tritschler, L., M. A. Kheirbek, Y. L. Dantec, I. Mendez-David, J. P. Guilloux, C. Faye, J. Doan, T. H. Pham, R. Hen, D. J. David and A. M. Gardier (2017). « Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens. » Neurosci Res.
Mendez-David, I., J. P. Guilloux, M. Papp, L. Tritschler, E. Mocaer, A. M. Gardier, S. Bretin and D. J. David (2017). « S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms. » Front Pharmacol 8: 462.
Nautiyal, K. M., L. Tritschler, S. E. Ahmari, D. J. David, A. M. Gardier and R. Hen (2016). « A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors. » Neuropsychopharmacology.
Pham, T. H., I. Mendez-David, C. Defaix, B. P. Guiard, L. Tritschler, D. J. David and A. M. Gardier (2017). « Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB/cJ mice. » Neuropharmacology 112(Pt A): 198-209.
David D. J., L. Tritschler, J. P. Guilloux, A. M. Gardier, C. Sanchez, R. Gaillard (2016). « Pharmacological properties of vortioxetine and its pre-clinical consequences. » Encéphale. 42: 1S12
Mendez-David, I., L. Tritschler, Z. E. Ali, M. H. Damiens, M. Pallardy, D. J. David, S. Kerdine-Romer and A. M. Gardier (2015). « Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression. » Neurosci Lett 597: 121-126.
Nautiyal, K. M., L. Tritschler, S. E. Ahmari, D. J. David, A. M. Gardier and R. Hen (2016). « A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors. » Neuropsychopharmacology 41(12): 2941-2950.
Tritschler, L., D. Felice, R. Colle, J. P. Guilloux, E. Corruble, A. M. Gardier and D. J. David (2014). « Vortioxetine for the treatment of major depressive disorder. » Expert Rev Clin Pharmacol: 1-15.
Darcet, F., I. Mendez-David, L. Tritschler, A. M. Gardier, J. P. Guilloux and D. J. David (2014). « Learning and memory impairments in a neuroendocrine mouse model of anxiety/depression. » Front Behav Neurosci 8: 136.
Ansar, S., E. Chatzikonstantinou, R. Thiagarajah, L. Tritschler, M. Fatar, M. G. Hennerici and S. Meairs (2014). « Pro-Inflammatory Mediators and Apoptosis Correlate to rt-PA Response in a Novel Mouse Model of Thromboembolic Stroke. » PLoS One 9(1): e85849.
Lehmann, O., H. Jeltsch, C. Lazarus, L. Tritschler, F. Bertrand and J. C. Cassel (2002). « Combined 192 IgG-saporin and 5,7-dihydroxytryptamine lesions in the male rat brain: a neurochemical and behavioral study. » Pharmacol Biochem Behav 72(4): 899-912.
Tritschler, L., M. Saboureau, P. Pevet and B. Bothorel (2006). « A functional subdivision of the circadian clock is revealed by differential effects of melatonin administration. » Neurosci Lett 396(1): 73-76.
Seminatore, C., J. Polentes, D. Ellman, N. Kozubenko, V. Itier, S. Tine, L. Tritschler, M. Brenot, E. Guidou, J. Blondeau, M. Lhuillier, A. Bugi, L. Aubry, P. Jendelova, E. Sykova, A. L. Perrier, B. Finsen and B. Onteniente (2010). « The postischemic environment differentially impacts teratoma or tumor formation after transplantation of human embryonic stem cell-derived neural progenitors. » Stroke 41(1): 153-159.