Université Paris Saclay, Bâtiment Henri Moissan
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Mois : octobre 2021

Plasma acetyl-l-carnitine and l-carnitine in major depressive episodes: a case-control study before and after treatment

Our data suggest a decreased mitochondrial metabolism of l-carnitine into ALC during MDE. This decreased mitochondrial metabolism is restored after a 6-month antidepressant treatment. Moreover, the magnitude of mitochondrial dysfunction may predict remission after 3 months of antidepressant treatment. New strategies targeting mitochondria should be explored to improve treatments of MDD. https://pubmed.ncbi.nlm.nih.gov/35115069/

Reviving through human hippocampal newborn neurons

Recent contradictory data has renewed discussion regarding the existence of adult hippocampal neu- rogenesis (AHN) in humans, i.e., the continued production of new neurons in the brain after birth. The present review revisits the debate of AHN in humans from a historical point of view in the face of con- tradictory evidence, analyzing the methods employed…
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