{"id":496,"date":"2022-08-03T13:20:32","date_gmt":"2022-08-03T12:20:32","guid":{"rendered":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/?page_id=496"},"modified":"2024-06-27T08:17:03","modified_gmt":"2024-06-27T07:17:03","slug":"sofia-cussotto","status":"publish","type":"page","link":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/?page_id=496","title":{"rendered":"Sofia Cussotto"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-resized is-style-rounded\"><a href=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/Cussotto.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/Cussotto-1024x1024.jpg\" alt=\"\" class=\"wp-image-495\" style=\"width:225px;height:225px\" width=\"225\" height=\"225\" srcset=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/Cussotto-1024x1024.jpg 1024w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/Cussotto-300x300.jpg 300w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/Cussotto-150x150.jpg 150w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/Cussotto-768x768.jpg 768w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/Cussotto.jpg 1046w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Assistant Professor in Pharmacology<\/h2>\n\n\n\n<p class=\"has-text-align-left\">PhD<\/p>\n\n\n\n<p class=\"has-text-align-left\">Tel: &nbsp;+33(0)1.80.00.63.28<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div 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wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/orcid.org\/0000-0002-2479-6985\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/1024px-ORCID_iD.svg_.png\" alt=\"\" class=\"wp-image-580\" style=\"object-fit:cover;width:30px;height:30px\" width=\"30\" height=\"30\" srcset=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/1024px-ORCID_iD.svg_.png 1024w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/1024px-ORCID_iD.svg_-300x300.png 300w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/1024px-ORCID_iD.svg_-150x150.png 150w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/1024px-ORCID_iD.svg_-768x768.png 768w\" sizes=\"(max-width: 30px) 100vw, 30px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large is-resized\"><a href=\"https:\/\/scholar.google.com\/citations?user=SXEyhAUAAAAJ&amp;hl=en&amp;oi=ao\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon-1024x1024.png\" alt=\"\" class=\"wp-image-583\" style=\"width:30px;height:30px\" width=\"30\" height=\"30\" srcset=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon-1024x1024.png 1024w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon-300x300.png 300w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon-150x150.png 150w, 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style=\"object-fit:cover;width:30px;height:30px\" width=\"30\" height=\"30\" srcset=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/RG.svg_.png 1024w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/RG.svg_-300x300.png 300w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/RG.svg_-150x150.png 150w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/RG.svg_-768x768.png 768w\" sizes=\"(max-width: 30px) 100vw, 30px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large is-resized\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=cussotto%2Bs&amp;sort=date\"><img decoding=\"async\" src=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/US-NLM-PubMed-Logo.svg_-1024x364.png\" alt=\"\" class=\"wp-image-591\" style=\"height:30px\" height=\"30\" srcset=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/US-NLM-PubMed-Logo.svg_-1024x364.png 1024w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/US-NLM-PubMed-Logo.svg_-300x107.png 300w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/US-NLM-PubMed-Logo.svg_-768x273.png 768w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/US-NLM-PubMed-Logo.svg_.png 1440w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul class=\"wp-block-social-links is-layout-flex wp-block-social-links-is-layout-flex\"><li class=\"wp-social-link wp-social-link-twitter  wp-block-social-link\"><a href=\"https:\/\/twitter.com\/CussottoSofia%20\" class=\"wp-block-social-link-anchor\"><svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M22.23,5.924c-0.736,0.326-1.527,0.547-2.357,0.646c0.847-0.508,1.498-1.312,1.804-2.27 c-0.793,0.47-1.671,0.812-2.606,0.996C18.324,4.498,17.257,4,16.077,4c-2.266,0-4.103,1.837-4.103,4.103 c0,0.322,0.036,0.635,0.106,0.935C8.67,8.867,5.647,7.234,3.623,4.751C3.27,5.357,3.067,6.062,3.067,6.814 c0,1.424,0.724,2.679,1.825,3.415c-0.673-0.021-1.305-0.206-1.859-0.513c0,0.017,0,0.034,0,0.052c0,1.988,1.414,3.647,3.292,4.023 c-0.344,0.094-0.707,0.144-1.081,0.144c-0.264,0-0.521-0.026-0.772-0.074c0.522,1.63,2.038,2.816,3.833,2.85 c-1.404,1.1-3.174,1.756-5.096,1.756c-0.331,0-0.658-0.019-0.979-0.057c1.816,1.164,3.973,1.843,6.29,1.843 c7.547,0,11.675-6.252,11.675-11.675c0-0.178-0.004-0.355-0.012-0.531C20.985,7.47,21.68,6.747,22.23,5.924z\"><\/path><\/svg><span class=\"wp-block-social-link-label screen-reader-text\">Twitter<\/span><\/a><\/li><\/ul>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Area of Research<\/h3>\n\n\n\n<p>Gut-brain axis, Immunopsychiatry, Nutrition, Neuropharmacology, Neurobiology of anxiety\/depression.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Expertise<\/h3>\n\n\n\n<p>Dr. Cussotto has a strong expertise in microbiology, animal behaviour, translational research, molecular biology, and immunohistochemistry.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Research Theme<\/h3>\n\n\n\n<p>Dr Sofia Cussotto graduated from a Master of Pharmacy in 2016 at University of Milan. For her Master thesis, she carried out a research internship at University College Cork (Ireland), in the laboratory of Prof. John Cryan. More and more fascinated by the gut-brain connection, she pursued a PhD in the same laboratory. Specifically, she tested the hypothesis that certain psychotropic medications would influence the gut microbiota and <em>vice versa<\/em>, changes in microbiota would affect drug\u2019s pharmacokinetics. From 2019 to 2022 she carried out her postdoc in Dr. Lucile Capuron\u2019s lab (INRAE), with a translational research approach at the interface between preclinical and clinical experiments, while keeping a strong focus on neuroscience and adding a nutritional component. During her postdoc she has focused on the link between nutritional status and depressive symptoms, with emphasis on the potential mediating role of inflammation.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Selected Publications<\/h3>\n\n\n\n<p>Golbaghi, N., S. Naeimi, A. Darvishi, N. Najari and <strong><span style=\"text-decoration: underline;\">S. Cussotto<\/span><\/strong> (2024). \u00ab\u00a0Probiotics in autism spectrum disorder: Recent insights from animal models.\u00a0\u00bb Autism: 13623613241246911.<\/p>\n\n\n\n<p>Vancassel S, Fanet H, Castanon N, Moncheaux De Oliveira C,<strong> <u>Cussotto S<\/u><\/strong>, Capuron L, Tetrahydrobiopterin modulates the behavioral neuroinflammatory response to an LPS challenge in mice, <em>Brain, Behavior, and Immunity<\/em>, In Press.<\/p>\n\n\n\n<p><strong><u>Cussotto S<\/u><\/strong>, Delgado I, Oriolo G, Kemper J, Begarie D, Dexpert S, Sauvant J, Leboyer M, Aouizerate B, Martin-Santos R, Schaefer M, Capuron L, Low Omega-3 Polyunsaturated Fatty Acids Predict Reduced Response to Standard Antidepressants in Patients with Major Depressive Disorder, <em>Depression&amp;Anxiety.<\/em> 2022 Mar, 39(5):407-418.<\/p>\n\n\n\n<p>Delgado I, <strong><u>Cussotto S<\/u><\/strong>, Anesi A, Dexpert S, Aubert A, Aouizerate B, Beau C, Forestier D, Ledaguenel P, Magne E, Mattivi F, Capuron L, Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study, <em>Int J of Obesity.<\/em> 2022 Apr; 46(4):885-888.<\/p>\n\n\n\n<p><strong><u>Cussotto S<\/u><\/strong>, Aouizerate B, Capuron L, From Gut to Brain: Microbiota Depletion in Mice as a Tool to Explore Causality, <em>Brain, Behavior, and Immunity<\/em>. 2021 May;94:4-5.<\/p>\n\n\n\n<p><strong><u>Cussotto S<\/u><\/strong>*, Delgado I*, Anesi A, Dexpert S, Aubert A, Beau C, Forestier D, Ledaguennel P, Magne E, Mattivi F, Capuron L, Tryptophan metabolic pathways are altered in obesity and are associated with systemic inflammation,<em> Front Immunol.<\/em> 2020 Apr; 11:557. *<strong><em>equal<\/em><\/strong><\/p>\n\n\n\n<p><strong><u>Cussotto S<\/u><\/strong>*, Walsh J*, Golubeva AV, Zhadov AV, Strain CR, Fouhy F, Stanton C, Dinan TG, Hyland N, Clarke G, Cryan JF, Griffin B, The gut microbiome influences the bioavailability of olanzapine in rats, <em>EBioMedicine<\/em>. 2021 Apr;66:103307. *<strong><em>equal<\/em><\/strong><\/p>\n\n\n\n<p><strong><u>Cussotto S<\/u><\/strong>, Clarke G, Dinan TG, Cryan JF (invited chapter). Psychotropic drugs and the microbiome. <em>Modern Trends in Psychiatry. Basel, Karger, 2021, vol. 32<\/em><\/p>\n\n\n\n<p>Bastiaanssen TFS*, <strong><u>Cussotto S<\/u><\/strong>*, Claesson MJ, Clarke G, Dinan TG, Cryan JF, Gutted! Unravelling the Role of the Microbiome in Major Depressive Disorder, <em>Harvard Rev Psych.<\/em>2020 Jan;28:26-39. *<strong><em>equal<\/em><\/strong><\/p>\n\n\n\n<p>Cryan JF, O&rsquo;Riordan, KJ, Cowan CSM, Bastiaanssen TFS, Boehme M, Codagnone MG, <strong><u>Cussotto S<\/u><\/strong>, Fulling C, Golubeva AV, Guzzetta KE, Long-Smith CM, Lyte JM, Martin J, Moloney GM, Morelli E, Morillas E, O\u2019Connor R, Pereira J, Peterson VL, Rea K, Ritz NL, Sandhu KV, Sherwin E, Spichak S, van de Wouw M, Ventura Silva AP, Wallace-Fitzsimons SE, Hyland N, Clarke G, Dinan TG. The Microbiota-Gut-Brain Axis, <em>Physiol Rev<\/em>. 2019 Oct 1; 99(4):1877-2013.<\/p>\n\n\n\n<p><strong><u>Cussotto S<\/u><\/strong>, Clarke G, Dinan TG, Cryan JF, Psychotropics and the Microbiome: A Chamber of Secrets. <em>Psychopharmacology<\/em>. 2019 May; 236:1411-1432.<\/p>\n\n\n\n<p><strong><u>Cussotto S<\/u><\/strong>, Strain CR, Fouhy F, Strain RG, Peterson VL, Clarke G, Stanton C, Dinan TG, Cryan JF, Differential Effects of Psychotropic Drugs on Microbiome Composition and Gastrointestinal Function, <em>Psychopharmacology.<\/em> 2019 May; 236(5):1671-1685.<\/p>\n\n\n\n<p><strong><u>Cussotto S<\/u><\/strong>, Sandhu KV, Dinan TG, Cryan JF, The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective, <em>Front Neuroendocrinol<\/em>. 2018 Oct; 51:80-101.<\/p>\n\n\n\n<p><strong><u>Cussotto S<\/u><\/strong>, Cryan JF, O\u2019Leary OF, The hippocampus and dorsal raphe nucleus are key brain areas associated with the antidepressant effects of lithium augmentation of desipramine, <em>Neuroscience Letters<\/em>, 648 (2017), pp. 14-20.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Past funded projects<\/h3>\n\n\n\n<p>2021 &#8211;&nbsp;<em>FRM (Fondation pour la Recherche Medicale)&nbsp;<\/em>&#8211; post-doctoral bursary<\/p>\n\n\n\n<p>2020 &#8211;&nbsp;<em>INRAE,<\/em>&nbsp;<em>D\u00e9partement Alimentation Humaine<\/em>&nbsp;&#8211; post-doctoral bursary<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Awards<\/h3>\n\n\n\n<p>2019 &#8211; Poster award: \u20ac 500 awarded at the 32nd European Congress on Neuropsychopharmacology (ECNP), Copenhagen<\/p>\n\n\n\n<p>2018 &#8211; Finalist,&nbsp;<em>ResearchFest competition, Dublin<\/em><\/p>\n\n\n\n<p>2018 &#8211; Finalist,&nbsp;<em>UCC Science for All competition, Cork<\/em><\/p>\n\n\n\n<p>2016 &#8211; Erasmus+ Scholarship, European Union<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Travel Awards&nbsp;<\/h3>\n\n\n\n<p>2019 &#8211;&nbsp;<em>ECNP<\/em>&nbsp;&#8211; \u20ac 500 awarded to attend the 32nd ECNP Congress, Copenhagen<\/p>\n\n\n\n<p>2019<em>&nbsp;&#8211; Department of Anatomy and Neuroscience (UCC) &#8211;&nbsp;<\/em>\u20ac 500 awarded to attend the ECNP workshop for early career junior scientists, Nice<\/p>\n\n\n\n<p>2018 &#8211;&nbsp;<em>College of Medicine and Health (UCC)<\/em>&nbsp;&#8211; \u20ac 1,000 awarded to attend the advanced course \u201cMicrobiota and the Brain\u201d, Neuroscience School of Advanced Studies, 2-9 June 2018, Venice<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Assistant Professor in Pharmacology PhD Tel: &nbsp;+33(0)1.80.00.63.28 Area of Research Gut-brain axis, Immunopsychiatry, Nutrition, Neuropharmacology, Neurobiology of anxiety\/depression. Expertise Dr. Cussotto has a strong expertise in microbiology, animal behaviour, translational research, molecular biology, and immunohistochemistry. Research Theme Dr Sofia Cussotto graduated from a Master of Pharmacy in 2016 at University of Milan. For her Master&hellip; <br \/> <a class=\"read-more\" href=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/?page_id=496\">Lire la suite<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/496"}],"collection":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=496"}],"version-history":[{"count":17,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/496\/revisions"}],"predecessor-version":[{"id":609,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/496\/revisions\/609"}],"wp:attachment":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=496"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}