{"id":470,"date":"2022-08-03T10:27:42","date_gmt":"2022-08-03T09:27:42","guid":{"rendered":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/?page_id=470"},"modified":"2024-06-27T06:40:58","modified_gmt":"2024-06-27T05:40:58","slug":"yann-pelloux","status":"publish","type":"page","link":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/?page_id=470","title":{"rendered":"Yann Pelloux"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full is-resized is-style-rounded\"><a href=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/2022_YP-1.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/2022_YP-1.jpg\" alt=\"\" class=\"wp-image-488\" style=\"width:255px;height:255px\" width=\"255\" height=\"255\" srcset=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/2022_YP-1.jpg 660w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/2022_YP-1-300x300.jpg 300w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/08\/2022_YP-1-150x150.jpg 150w\" sizes=\"(max-width: 255px) 100vw, 255px\" \/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Junior Professor in Pharmacology<\/h2>\n\n\n\n<p class=\"has-text-align-left\">PhD<\/p>\n\n\n\n<p class=\"has-text-align-left\">Tel: \u00a0+33(0)1.80.00.63.29<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul class=\"wp-block-social-links is-layout-flex wp-block-social-links-is-layout-flex\"><li class=\"wp-social-link wp-social-link-mail  wp-block-social-link\"><a 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src=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/1024px-ORCID_iD.svg_.png\" alt=\"\" class=\"wp-image-580\" style=\"object-fit:cover;width:30px;height:30px\" width=\"30\" height=\"30\" srcset=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/1024px-ORCID_iD.svg_.png 1024w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/1024px-ORCID_iD.svg_-300x300.png 300w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/1024px-ORCID_iD.svg_-150x150.png 150w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/1024px-ORCID_iD.svg_-768x768.png 768w\" sizes=\"(max-width: 30px) 100vw, 30px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large is-resized\"><a href=\"https:\/\/scholar.google.com\/citations?user=3NszDhwAAAAJ&amp;hl=en\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon-1024x1024.png\" alt=\"\" class=\"wp-image-583\" style=\"object-fit:cover;width:30px;height:30px\" width=\"30\" height=\"30\" srcset=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon-1024x1024.png 1024w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon-300x300.png 300w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon-150x150.png 150w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon-768x768.png 768w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon-1536x1536.png 1536w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon-1080x1080.png 1080w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/google-scholar-icon.png 2048w\" sizes=\"(max-width: 30px) 100vw, 30px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.researchgate.net\/profile\/Yann-Pelloux\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/RG.svg_.png\" alt=\"\" class=\"wp-image-589\" style=\"object-fit:cover;width:30px;height:30px\" width=\"30\" height=\"30\" srcset=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/RG.svg_.png 1024w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/RG.svg_-300x300.png 300w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/RG.svg_-150x150.png 150w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/RG.svg_-768x768.png 768w\" sizes=\"(max-width: 30px) 100vw, 30px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large is-resized\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=pelloux+y&amp;sort=date&amp;size=200\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2024\/06\/US-NLM-PubMed-Logo.svg_-1024x364.png\" alt=\"\" class=\"wp-image-591\" style=\"object-fit:cover;width:30px;height:30px\" width=\"30\" height=\"30\"\/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Area of research<\/h3>\n\n\n\n<p>Neuropharmacology, Neurobiology of addiction and emotional behavior, Animal Models of Psychiatric Disorders.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Expertise<\/h3>\n\n\n\n<p>Neuropsychological substrate of mental disorders with a particular emphasize on addictive disorders with recently a broader approach on physiological and pathological decision making<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Research Theme<\/h3>\n\n\n\n<p>Dr Yann Pelloux graduated in 2003 in the laboratory of experimental neuropsychopharmacology at the university of Rouen under the supervision of professor Jean Costentin and doctor Dominique Duterte-Boucher investigating the role of various behavioural traits in the predisposition to use drugs in rodents. He then moved to Cambridge in the United Kingdom for a first post doc in the department of experimental psychology under the supervision of professor Barry Everitt working on the neuropsychological substrate of compulsive cocaine seeking. He then moved to the Bagamore laboratory of the institute of Neuroscience of La Timone in Marseille under the supervision of the doctor Christelle Baunez looking at the pertinence of targeting the subthalamic nucleus for the application of deep brain stimulation in the treatment of addictive disorders. Having been granted a NIDA\/INSERM fellowship he moved to the national institute on drug abuse in Baltimore in the United States under the supervision of Yavin Shaham working on the neural basis of relapse to cocaine seeking and then moved in the Adam Mar\u2019s lab at the department of neuroscience and physiology at the Langone center of New York University, investigating the role of cholinergic transmission in various mental disorders. Then granted a Marie Curie fellowship, he moved to the neuromodulation of cortical and subcortical systems laboratory of doctor Raffaella Tonini in Genoa Italy working on the role of serotoninergic transmission in decision making under uncertainty. He recently joined the CESP Mood where is currently working on the decision-making alteration in depressive disorders and its underlying brain mechanisms. He is using viral, genetic and pharmacological and electrical tools combined with parametric and rigorous behavioural manipulations and analysis to monitor or manipulate neural circuit activity and uncover the neural circuit dynamics responsible for making decision. He is collaborating with the different members of the lab to improve treatments against depressive disorders and prevent relapse through multidisciplinary and translational approach, from molecule to complex behaviour and from bench to bedside.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Selected Publications<\/h3>\n\n\n\n<p>Giorla, E., S. Nordmann, C. Vielle, Y. Pelloux, P. Roux, C. Protopopescu, C. Manrique, K. Davranche, C. Montanari, L. Giorgi, A. Vilotitch, P. Huguet, P. Carrieri and C. Baunez (2022). \u00ab\u00a0Peer presence and familiarity as key factors to reduce cocaine intake in both rats and humans: an effect mediated by the subthalamic nucleus.\u00a0\u00bb Psychopharmacology (Berl) 239(4): 1097-1113.<\/p>\n\n\n\n<p><br>Vielle, C., C. Montanari, Y. Pelloux and C. Baunez (2021). \u00ab\u00a0Evidence for a vocal signature in the rat and its reinforcing effects: a key role for the subthalamic nucleus.\u00a0\u00bb Proc Biol Sci 288(1965): 20212260.<\/p>\n\n\n\n<p><br>Degoulet, M., A. Tiran-Cappello, E. Combrisson, C. Baunez and Y. Pelloux (2021). \u00ab\u00a0Subthalamic low-frequency oscillations predict vulnerability to cocaine addiction.\u00a0\u00bb Proc Natl Acad Sci U S A 118(14).<br>Boender, A. J., L. Bontempi, L. Nava, Y. Pelloux and R. Tonini (2021). \u00ab\u00a0Striatal Astrocytes Shape Behavioral Flexibility via Regulation of the Glutamate Transporter EAAT2.\u00a0\u00bb Biol Psychiatry 89(11): 1045-1057.<\/p>\n\n\n\n<p>Breysse, E., J. Meffre, Y. Pelloux, C. A. Winstanley and C. Baunez (2021). \u00ab\u00a0Decreased risk-taking and loss-chasing after subthalamic nucleus lesion in rats.\u00a0\u00bb Eur J Neurosci 53(7): 2362-2375.<br>Pelloux, Y., E. Giorla, C. Montanari and C. Baunez (2019). \u00ab\u00a0Social modulation of drug use and drug addiction.\u00a0\u00bb Neuropharmacology 159: 107545.<\/p>\n\n\n\n<p><br>Montanari, C., E. Giorla, Y. Pelloux and C. Baunez (2020). \u00ab\u00a0Subthalamic nucleus mediates the modulation on cocaine self-administration induced by ultrasonic vocalization playback in rats.\u00a0\u00bb Addict Biol 25(1): e12710.<br><\/p>\n\n\n\n<p>Pelloux, Y., M. Degoulet, A. Tiran-Cappello, C. Cohen, S. Lardeux, O. George, G. F. Koob, S. H. Ahmed and C. Baunez (2018). \u00ab\u00a0Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use.\u00a0\u00bb Mol Psychiatry 23(12): 2266-2276.<\/p>\n\n\n\n<p><br>Marchant, N. J., E. J. Campbell, Y. Pelloux, J. M. Bossert and Y. Shaham (2019). \u00ab\u00a0Context-induced relapse after extinction versus punishment: similarities and differences.\u00a0\u00bb Psychopharmacology (Berl) 236(1): 439-448.<\/p>\n\n\n\n<p><br>Pelloux, Y., A. Minier-Toribio, J. K. Hoots, J. M. Bossert and Y. Shaham (2018). \u00ab\u00a0Opposite Effects of Basolateral Amygdala Inactivation on Context-Induced Relapse to Cocaine Seeking after Extinction versus Punishment.\u00a0\u00bb J Neurosci 38(1): 51-59.<\/p>\n\n\n\n<p><br>Pelloux, Y., J. K. Hoots, C. Cifani, S. Adhikary, J. Martin, A. Minier-Toribio, J. M. Bossert and Y. Shaham (2018). \u00ab\u00a0Context-induced relapse to cocaine seeking after punishment-imposed abstinence is associated with activation of cortical and subcortical brain regions.\u00a0\u00bb Addict Biol 23(2): 699-712.<\/p>\n\n\n\n<p><br>Pelloux, Y. and C. Baunez (2017). \u00ab\u00a0Targeting the subthalamic nucleus in a preclinical model of alcohol use disorder.\u00a0\u00bb Psychopharmacology (Berl) 234(14): 2127-2137.<\/p>\n\n\n\n<p><br>Breysse, E., Y. Pelloux and C. Baunez (2015). \u00ab\u00a0The Good and Bad Differentially Encoded within the Subthalamic Nucleus in Rats(1,2,3).\u00a0\u00bb eNeuro 2(5).<\/p>\n\n\n\n<p><br>Pelloux, Y. and C. Baunez (2015). \u00ab\u00a0[Surgical strategy to rescue the addicts].\u00a0\u00bb Med Sci (Paris) 31(6-7): 674-679.<\/p>\n\n\n\n<p><br>Pelloux, Y., J. Costentin and D. Duterte-Boucher (2015). \u00ab\u00a0Differential involvement of anxiety and novelty preference levels on oral ethanol consumption in rats.\u00a0\u00bb Psychopharmacology (Berl) 232(15): 2711-2721.<\/p>\n\n\n\n<p><br>Pelloux, Y., J. Meffre, E. Giorla and C. Baunez (2014). \u00ab\u00a0The subthalamic nucleus keeps you high on emotion: behavioral consequences of its inactivation.\u00a0\u00bb Front Behav Neurosci 8: 414.<\/p>\n\n\n\n<p><br>Pelloux, Y., J. E. Murray and B. J. Everitt (2015). \u00ab\u00a0Differential vulnerability to the punishment of cocaine related behaviours: effects of locus of punishment, cocaine taking history and alternative reinforcer availability.\u00a0\u00bb Psychopharmacology (Berl) 232(1): 125-134.<\/p>\n\n\n\n<p><br>Murray, J. E., R. Dilleen, Y. Pelloux, D. Economidou, J. W. Dalley, D. Belin and B. J. Everitt (2014). \u00ab\u00a0Increased impulsivity retards the transition to dorsolateral striatal dopamine control of cocaine seeking.\u00a0\u00bb Biol Psychiatry 76(1): 15-22.<\/p>\n\n\n\n<p><br>Nougaret, S., J. Meffre, Y. Duclos, E. Breysse and Y. Pelloux (2013). \u00ab\u00a0First evidence of a hyperdirect prefrontal pathway in the primate: precise organization for new insights on subthalamic nucleus functions.\u00a0\u00bb Front Comput Neurosci 7: 135.<\/p>\n\n\n\n<p><br>Coura, R. S., A. Cressant, J. Xia, F. de Chaumont, J. C. Olivo-Marin, Y. Pelloux, J. W. Dalley and S. Granon (2013). \u00ab\u00a0Nonaggressive and adapted social cognition is controlled by the interplay between noradrenergic and nicotinic receptor mechanisms in the prefrontal cortex.\u00a0\u00bb FASEB J 27(11): 4343-4354.<\/p>\n\n\n\n<p><br>Pelloux, Y., J. E. Murray and B. J. Everitt (2013). \u00ab\u00a0Differential roles of the prefrontal cortical subregions and basolateral amygdala in compulsive cocaine seeking and relapse after voluntary abstinence in rats.\u00a0\u00bb Eur J Neurosci 38(7): 3018-3026.<\/p>\n\n\n\n<p><br>Besson, M., Y. Pelloux, R. Dilleen, D. E. Theobald, A. Lyon, A. Belin-Rauscent, T. W. Robbins, J. W. Dalley, B. J. Everitt and D. Belin (2013). \u00ab\u00a0Cocaine modulation of frontostriatal expression of Zif268, D2, and 5-HT2c receptors in high and low impulsive rats.\u00a0\u00bb Neuropsychopharmacology 38(10): 1963-1973.<\/p>\n\n\n\n<p><br>Pelloux, Y. and C. Baunez (2013). \u00ab\u00a0Deep brain stimulation for addiction: why the subthalamic nucleus should be favored.\u00a0\u00bb Curr Opin Neurobiol 23(4): 713-720.<\/p>\n\n\n\n<p><br>Pelloux, Y., R. Dilleen, D. Economidou, D. Theobald and B. J. Everitt (2012). \u00ab\u00a0Reduced forebrain serotonin transmission is causally involved in the development of compulsive cocaine seeking in rats.\u00a0\u00bb Neuropsychopharmacology 37(11): 2505-2514.<\/p>\n\n\n\n<p><br>Jonkman, S., Y. Pelloux and B. J. Everitt (2012). \u00ab\u00a0Differential roles of the dorsolateral and midlateral striatum in punished cocaine seeking.\u00a0\u00bb J Neurosci 32(13): 4645-4650.<\/p>\n\n\n\n<p><br>Jonkman, S., Y. Pelloux and B. J. Everitt (2012). \u00ab\u00a0Drug intake is sufficient, but conditioning is not necessary for the emergence of compulsive cocaine seeking after extended self-administration.\u00a0\u00bb Neuropsychopharmacology 37(7): 1612-1619.<\/p>\n\n\n\n<p><br>Dilleen, R., Y. Pelloux, A. C. Mar, A. Molander, T. W. Robbins, B. J. Everitt, J. W. Dalley and D. Belin (2012). \u00ab\u00a0High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats.\u00a0\u00bb Psychopharmacology (Berl) 222(1): 89-97.<\/p>\n\n\n\n<p><br>Economidou, D., Y. Pelloux, T. W. Robbins, J. W. Dalley and B. J. Everitt (2009). \u00ab\u00a0High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence.\u00a0\u00bb Biol Psychiatry 65(10): 851-856.<br>Pelloux, Y., J. Costentin and D. Duterte-Boucher (2009). \u00ab\u00a0Anxiety increases the place conditioning induced by cocaine in rats.\u00a0\u00bb Behav Brain Res 197(2): 311-316.<\/p>\n\n\n\n<p><br>Everitt, B. J., D. Belin, D. Economidou, Y. Pelloux, J. W. Dalley and T. W. Robbins (2008). \u00ab\u00a0Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction.\u00a0\u00bb Philos Trans R Soc Lond B Biol Sci 363(1507): 3125-3135.<\/p>\n\n\n\n<p><br>Everitt, B. J., D. M. Hutcheson, K. D. Ersche, Y. Pelloux, J. W. Dalley and T. W. Robbins (2007). \u00ab\u00a0The orbital prefrontal cortex and drug addiction in laboratory animals and humans.\u00a0\u00bb Ann N Y Acad Sci 1121: 576-597.<\/p>\n\n\n\n<p><br>Pelloux, Y., B. J. Everitt and A. Dickinson (2007). \u00ab\u00a0Compulsive drug seeking by rats under punishment: effects of drug taking history.\u00a0\u00bb Psychopharmacology (Berl) 194(1): 127-137.<\/p>\n\n\n\n<p><br>Pelloux, Y., J. Costentin and D. Duterte-Boucher (2006). \u00ab\u00a0Novelty preference predicts place preference conditioning to morphine and its oral consumption in rats.\u00a0\u00bb Pharmacol Biochem Behav 84(1): 43-50.<br>Vautrin, S., Y. Pelloux and J. Costentin (2005). \u00ab\u00a0Preference for caffeine appears earlier in non-anxious than in anxious mice.\u00a0\u00bb Neurosci Lett 386(2): 94-98.<\/p>\n\n\n\n<p><br>Pelloux, Y., G. Hagues, J. Costentin and D. Duterte-Boucher (2005). \u00ab\u00a0Helplessness in the tail suspension test is associated with an increase in ethanol intake and its rewarding effect in female mice.\u00a0\u00bb Alcohol Clin Exp Res 29(3): 378-388.<\/p>\n\n\n\n<p><br>Pelloux, Y., J. Costentin and D. Duterte-Boucher (2004). \u00ab\u00a0Differential effects of novelty exposure on place preference conditioning to amphetamine and its oral consumption.\u00a0\u00bb Psychopharmacology (Berl) 171(3): 277-285.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;&nbsp; Book Chapters<\/h3>\n\n\n\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Junior Professor in Pharmacology PhD Tel: \u00a0+33(0)1.80.00.63.29 Area of research Neuropharmacology, Neurobiology of addiction and emotional behavior, Animal Models of Psychiatric Disorders. Expertise Neuropsychological substrate of mental disorders with a particular emphasize on addictive disorders with recently a broader approach on physiological and pathological decision making Research Theme Dr Yann Pelloux graduated in 2003 in&hellip; <br \/> <a class=\"read-more\" href=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/?page_id=470\">Lire la suite<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/470"}],"collection":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=470"}],"version-history":[{"count":9,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/470\/revisions"}],"predecessor-version":[{"id":598,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/470\/revisions\/598"}],"wp:attachment":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}