{"id":286,"date":"2020-10-05T21:29:04","date_gmt":"2020-10-05T20:29:04","guid":{"rendered":"http:\/?page_id=286"},"modified":"2024-06-27T08:34:27","modified_gmt":"2024-06-27T07:34:27","slug":"celine-defaix","status":"publish","type":"page","link":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/?page_id=286","title":{"rendered":"C\u00e9line Defaix"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-resized is-style-rounded\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/wp-content\/uploads\/2020\/10\/2020_CD_NB-edited.jpg\" alt=\"\" class=\"wp-image-324\" style=\"width:208px;height:207px\" width=\"208\" height=\"207\" srcset=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/10\/2020_CD_NB-edited.jpg 1232w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/10\/2020_CD_NB-edited-300x300.jpg 300w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/10\/2020_CD_NB-edited-1024x1023.jpg 1024w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/10\/2020_CD_NB-edited-150x150.jpg 150w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/10\/2020_CD_NB-edited-768x767.jpg 768w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/10\/2020_CD_NB-edited-1081x1080.jpg 1081w\" sizes=\"(max-width: 208px) 100vw, 208px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Research Scientist<\/h2>\n\n\n\n<p>PhD<\/p>\n\n\n\n<p>Tel: +33.(0).1.80.00.63.38<\/p>\n\n\n\n<ul class=\"wp-block-social-links is-layout-flex wp-block-social-links-is-layout-flex\">\n\n\n\n\n\n\n\n\n\n\n\n<li class=\"wp-social-link wp-social-link-mail  wp-block-social-link\"><a href=\"mailto:celine.defaix@universite-paris-saclay.fr\" class=\"wp-block-social-link-anchor\"><svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M19,5H5c-1.1,0-2,.9-2,2v10c0,1.1.9,2,2,2h14c1.1,0,2-.9,2-2V7c0-1.1-.9-2-2-2zm.5,12c0,.3-.2.5-.5.5H5c-.3,0-.5-.2-.5-.5V9.8l7.5,5.6,7.5-5.6V17zm0-9.1L12,13.6,4.5,7.9V7c0-.3.2-.5.5-.5h14c.3,0,.5.2.5.5v.9z\"><\/path><\/svg><span class=\"wp-block-social-link-label screen-reader-text\">Mail<\/span><\/a><\/li><\/ul>\n\n\n\n<pre id=\"block-8b7cd01d-7a77-4322-aae8-a6718ce34fc2\" class=\"wp-block-preformatted\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/1RwZ2M7zagmgOr\/bibliography\/public\/\" target=\"_blank\" rel=\"noreferrer noopener\"><h3 class=\"wp-svg-library library\"><\/h3><\/a><\/pre>\n\n\n\n<h3 class=\"wp-block-heading\">Area of Research<\/h3>\n\n\n\n<p>Antidepressant action of ketamine in animal models of depression<\/p>\n\n\n\n<p><strong>Selected Publications<\/strong><\/p>\n\n\n\n<p>Nguyen, T. M. L., J.-P. Guilloux, C. Defaix, I. Mendez-David, I. Etting, J.-C. Alvarez, J. C. McGowan, J. N. Highland, P. Zanos, J. Lovett, R. Moaddel, E. Corruble, D. J. David, T. D. Gould, C. A. Denny and A. M. Gardier (2024). \u00ab\u00a0Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.\u00a0\u00bb bioRxiv.<br><\/p>\n\n\n\n<p>Nguyen, T. M. L., C. Defaix, I. Mendez-David, L. Tritschler, I. Etting, J. C. Alvarez, W. Choucha, R. Colle, E. Corruble, D. J. David and A. M. Gardier (2023). \u00ab\u00a0Intranasal (R, S)-ketamine delivery induces sustained antidepressant effects associated with changes in cortical balance of excitatory\/inhibitory synaptic activity.\u00a0\u00bb Neuropharmacology 225: 109357.<br><\/p>\n\n\n\n<p>Doan, J., C. Defaix, I. Mendez-David, A. M. Gardier, R. Colle, E. Corruble, J. C. McGowan, D. J. David, J. P. Guilloux and L. Tritschler (2023). \u00ab\u00a0Intrahippocampal injection of a selective blocker of NMDA receptors containing the GluN2B subunit, Ro25-6981, increases glutamate neurotransmission and induces antidepressant-like effects.\u00a0\u00bb Fundam Clin Pharmacol.<br><\/p>\n\n\n\n<p>Pham, T. H., C. Defaix, T. M. L. Nguyen, I. Mendez-David, L. Tritschler, D. J. David and A. M. Gardier (2020). \u00ab\u00a0Cortical and raphe GABAA, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine.\u00a0\u00bb Pharmacol Biochem Behav 192: 172913.<br><\/p>\n\n\n\n<p>Pham, T. H., C. Defaix, X. Xu, S. X. Deng, N. Fabresse, J. C. Alvarez, D. W. Landry, R. A. Brachman, C. A. Denny and A. M. Gardier (2018). \u00ab\u00a0Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.\u00a0\u00bb Biol Psychiatry 84(1): e3-e6.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Defaix C., A. Solgadi, T. H. Pham, A. M. Gardier, P. Chaminade, L. Tritschler (2018).\u00a0Rapid analysis of glutamate, glutamine and GABA in mice frontal cortex microdialysis samples using HPLC coupled to electrospray tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis.<\/p>\n\n\n\n<p>&nbsp;Pham, T. H., C. Defaix, X. Xu, S. X. Deng, N. Fabresse, J. C. Alvarez, D. W. Landry, R. A. Brachman, C. A. Denny and A. M. Gardier (2017). \u00ab\u00a0Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.\u00a0\u00bb Biol Psychiatry.<\/p>\n\n\n\n<p>&nbsp;Pham, T. H., I. Mendez-David, C. Defaix, B. P. Guiard, L. Tritschler, D. J. David and A. M. Gardier (2017). \u00ab\u00a0Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB\/cJ mice.\u00a0\u00bb Neuropharmacology 112(Pt A): 198-209.<\/p>\n\n\n\n<p>&nbsp;Lavialle-Defaix, C., V. Jacob, C. Monsempes, S. Anton, J. P. Rospars, D. Martinez and P. Lucas (2015). \u00ab\u00a0Firing and intrinsic properties of antennal lobe neurons in the Noctuid moth Agrotis ipsilon.\u00a0\u00bb Biosystems.<\/p>\n\n\n\n<p>\u00a0Lavialle-Defaix, C., V. Apaire-Marchais, C. Legros, C. Pennetier, A. Mohamed, P. Licznar, V. Corbel and B. Lapied (2011). \u00ab\u00a0Anopheles gambiae mosquito isolated neurons: a new biological model for optimizing insecticide\/repellent efficacy.\u00a0\u00bb J Neurosci Methods (1): 68-73.<\/p>\n\n\n\n<p>&nbsp;Lavialle-Defaix, C., B. Moignot, C. Legros and B. Lapied (2010). \u00ab\u00a0How does calcium-dependent intracellular regulation of voltage-dependent sodium current increase the sensitivity to the oxadiazine insecticide indoxacarb metabolite decarbomethoxylated JW062 (DCJW) in insect pacemaker neurons?\u00a0\u00bb J Pharmacol Exp Ther 333(1): 264-272.<\/p>\n\n\n\n<p>&nbsp;Lavialle-Defaix, C., H. Gautier, A. Defaix, B. Lapied and F. Grolleau (2006). \u00ab\u00a0Differential regulation of two distinct voltage-dependent sodium currents by group III metabotropic glutamate receptor activation in insect pacemaker neurons.\u00a0\u00bb J Neurophysiol 96(5): 2437-2450.<\/p>\n\n\n\n<p>&nbsp;Grolleau, F., M. Stankiewicz, E. Kielbasiewicz, M. F. Martin-Eauclaire, C. Lavialle, J. De Vente and B. Lapied (2006). \u00ab\u00a0Indirect activation of neuronal noncapacitative Ca2+ entry is the final step involved in the neurotoxic effect of Tityus serrulatus scorpion beta-toxin.\u00a0\u00bb Eur J Neurosci 23(6): 1465-1478.<\/p>\n\n\n\n<p>&nbsp;Wicher, D., S. Messutat, C. Lavialle and B. Lapied (2004). \u00ab\u00a0A new regulation of non-capacitative calcium entry in insect pacemaker neurosecretory neurons. Involvement of arachidonic acid, no-guanylyl cyclase\/cGMP, and cAMP.\u00a0\u00bb J Biol Chem 279(48): 50410-50419.<\/p>\n\n\n\n<p>&nbsp;Jean, I., C. Lavialle, A. Barthelaix-Pouplard and C. Fressinaud (2003). \u00ab\u00a0Neurotrophin-3 specifically increases mature oligodendrocyte population and enhances remyelination after chemical demyelination of adult rat CNS.\u00a0\u00bb Brain Res 972(1-2): 110-118.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp; Book Chapters<\/h3>\n\n\n\n<p>Grolleau, F., C. Lavialle and B. Lapied (2002). Canaux Ioniques Neuronaux d&rsquo;Insecte : Cibles pour des Toxines d&rsquo;Origine Animale. Toxines et Recherche Biom\u00e9dicale. F. Goudey-Perri\u00e8re, C. Bon, S. Puiseux-Dao and M. P. Sauviat. Paris, Collections Elsevier Scientifiques et M\u00e9dicales: 211-220.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Scientist PhD Tel: +33.(0).1.80.00.63.38 Area of Research Antidepressant action of ketamine in animal models of depression Selected Publications Nguyen, T. M. L., J.-P. Guilloux, C. Defaix, I. Mendez-David, I. Etting, J.-C. Alvarez, J. C. McGowan, J. N. Highland, P. Zanos, J. Lovett, R. Moaddel, E. Corruble, D. J. David, T. D. Gould, C. A.&hellip; <br \/> <a class=\"read-more\" href=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/?page_id=286\">Lire la suite<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/286"}],"collection":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=286"}],"version-history":[{"count":8,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/286\/revisions"}],"predecessor-version":[{"id":617,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/286\/revisions\/617"}],"wp:attachment":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}