{"id":152,"date":"2020-10-02T11:49:46","date_gmt":"2020-10-02T10:49:46","guid":{"rendered":"http:\/?page_id=152"},"modified":"2024-06-27T08:45:01","modified_gmt":"2024-06-27T07:45:01","slug":"laurent-tritschler","status":"publish","type":"page","link":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/?page_id=152","title":{"rendered":"Laurent Tritschler"},"content":{"rendered":"\n<figure class=\"wp-block-image is-resized is-style-rounded\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/wp-content\/uploads\/2020\/09\/2020_LT_NB.jpg\" alt=\"\" class=\"wp-image-111\" style=\"width:218px;height:225px\" width=\"218\" height=\"225\" srcset=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/09\/2020_LT_NB.jpg 523w, http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/wp-content\/uploads\/2020\/09\/2020_LT_NB-291x300.jpg 291w\" sizes=\"(max-width: 218px) 100vw, 218px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Assistant Professor<\/h2>\n\n\n\n<p>PhD<\/p>\n\n\n\n<p>Tel: &nbsp;+33(0)1.80.00.63.36<\/p>\n\n\n\n<ul class=\"wp-block-social-links is-layout-flex wp-block-social-links-is-layout-flex\">\n\n\n\n\n\n\n\n\n\n<li class=\"wp-social-link wp-social-link-mail  wp-block-social-link\"><a href=\"mailto:laurent.tritschler@universite-paris-saclay.fr\" class=\"wp-block-social-link-anchor\"><svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M19,5H5c-1.1,0-2,.9-2,2v10c0,1.1.9,2,2,2h14c1.1,0,2-.9,2-2V7c0-1.1-.9-2-2-2zm.5,12c0,.3-.2.5-.5.5H5c-.3,0-.5-.2-.5-.5V9.8l7.5,5.6,7.5-5.6V17zm0-9.1L12,13.6,4.5,7.9V7c0-.3.2-.5.5-.5h14c.3,0,.5.2.5.5v.9z\"><\/path><\/svg><span class=\"wp-block-social-link-label screen-reader-text\">Mail<\/span><\/a><\/li><\/ul>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/1-K-bdwyzJhIbb\/bibliography\/public\/\" target=\"_blank\" rel=\"noreferrer noopener\"><h3 class=\"wp-svg-library library\"><\/h3><\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Area of Research<\/h3>\n\n\n\n<p>Neuropharmacology, Neurobiology of anxiety\/depression, Animal Models of Psychiatric Disorders.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Expertise<\/h3>\n\n\n\n<p>Dr. Tritschler continues now to work in vivo, he is studying the effects of the activation level of the hippocampus on the depressive-like behaviour as well as the changes induced by this stimulation on the hippocampus related brain areas.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Research Theme<\/h3>\n\n\n\n<p>Before to join the laboratory, Dr. Tritschler performed a 3 years Postdoctoral position at the Department of Neurology at the Mannheim University Hospital, Germany Directed by Pr. S. Meairs. This has followed a 18-month stay at the ISTEM laboratory in Evry, France Directed by Dr. S. Onteniente, and a 18-month stay in the industry at sanofi-aventis, Vitry-sur-Seine, France, at the Department of neurodegenerative disease, directed by Drs. Duverger and Debeir. Dr. Tritschler completed his PhD thesis at the Laboratory of Neurobiology of Rhythms, Strasbourg, France.<\/p>\n\n\n\n<p>Dr. Tritschler was always interested in topics related to the physiology or physio-pathology and involving in vivo studies.<\/p>\n\n\n\n<p>During his PhD formation, he worked on the understanding of the circadian clock organisation by using two outputs of the clock: the melatonin and the corticosterone rhythms. For the following post-doctoral positions:<\/p>\n\n\n\n<p>-First, he developed and characterised a spinal cord injury model in the rat<\/p>\n\n\n\n<p>-Second, he worked on the relations between the graft and the host in the case of human stem cells graft in a rat model of striatal ischemia<\/p>\n\n\n\n<p>-Third, he studied the effects of mesenchymal stem cells conditioned medium on a rat model of the stroke.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Selected Publications<\/h3>\n\n\n\n<p>Nguyen, T. M. L., F. Jollant, L. Tritschler, R. Colle, E. Corruble and A. M. Gardier (2024). \u00ab\u00a0[Ketamine and suicidal behavior: Contribution of animal models of aggression-impulsivity to understanding its mechanism of action].\u00a0\u00bb Ann Pharm Fr 82(1): 3-14.<br><\/p>\n\n\n\n<p>Nguyen, T. M. L., F. Jollant, L. Tritschler, R. Colle, E. Corruble and A. M. Gardier (2023). \u00ab\u00a0Pharmacological Mechanism of Ketamine in Suicidal Behavior Based on Animal Models of Aggressiveness and Impulsivity: A Narrative Review.\u00a0\u00bb Pharmaceuticals (Basel) 16(4).<br><\/p>\n\n\n\n<p>Nguyen, T. M. L., C. Defaix, I. Mendez-David, L. Tritschler, I. Etting, J. C. Alvarez, W. Choucha, R. Colle, E. Corruble, D. J. David and A. M. Gardier (2023). \u00ab\u00a0Intranasal (R, S)-ketamine delivery induces sustained antidepressant effects associated with changes in cortical balance of excitatory\/inhibitory synaptic activity.\u00a0\u00bb Neuropharmacology 225: 109357.<br><\/p>\n\n\n\n<p>Doan, J., C. Defaix, I. Mendez-David, A. M. Gardier, R. Colle, E. Corruble, J. C. McGowan, D. J. David, J. P. Guilloux and L. Tritschler (2023). \u00ab\u00a0Intrahippocampal injection of a selective blocker of NMDA receptors containing the GluN2B subunit, Ro25-6981, increases glutamate neurotransmission and induces antidepressant-like effects.\u00a0\u00bb Fundam Clin Pharmacol.<br><\/p>\n\n\n\n<p>Mendez-David, I., R. Schofield, L. Tritschler, R. Colle, J. P. Guilloux, A. M. Gardier, E. Corruble, R. Hen and D. J. David (2022). \u00ab\u00a0Reviving through human hippocampal newborn neurons.\u00a0\u00bb Encephale 48(2): 179-187.<br><\/p>\n\n\n\n<p>Pham, T. H., C. Defaix, T. M. L. Nguyen, I. Mendez-David, L. Tritschler, D. J. David and A. M. Gardier (2020). \u00ab\u00a0Cortical and raphe GABAA, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine.\u00a0\u00bb Pharmacol Biochem Behav 192: 172913.<\/p>\n\n\n\n<p>Doan, J., A. M. Gardier and L. Tritschler (2019). \u00ab\u00a0Role of adult-born granule cells in the hippocampal functions: Focus on the GluN2B-containing NMDA receptors.\u00a0\u00bb Eur Neuropsychopharmacol. In press.<\/p>\n\n\n\n<p>&nbsp;Defaix C., A. Solgadi, T. H. Pham, A. M. Gardier, P. Chaminade, L. Tritschler (2018).&nbsp;Rapid analysis of glutamate, glutamine and GABA in mice frontal cortex microdialysis samples using HPLC coupled to electrospray tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis.<\/p>\n\n\n\n<p>&nbsp;Tritschler, L., M. A. Kheirbek, Y. L. Dantec, I. Mendez-David, J. P. Guilloux, C. Faye, J. Doan, T. H. Pham, R. Hen, D. J. David and A. M. Gardier (2017). \u00ab\u00a0Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens.\u00a0\u00bb Neurosci Res.<\/p>\n\n\n\n<p>&nbsp;Mendez-David, I., J. P. Guilloux, M. Papp, L. Tritschler, E. Mocaer, A. M. Gardier, S. Bretin and D. J. David (2017). \u00ab\u00a0S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms.\u00a0\u00bb Front Pharmacol 8: 462.<\/p>\n\n\n\n<p>&nbsp;Nautiyal, K. M., L. Tritschler, S. E. Ahmari, D. J. David, A. M. Gardier and R. Hen (2016). \u00ab\u00a0A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors.\u00a0\u00bb Neuropsychopharmacology.<\/p>\n\n\n\n<p>&nbsp;Pham, T. H., I. Mendez-David, C. Defaix, B. P. Guiard, L. Tritschler, D. J. David and A. M. Gardier (2017). \u00ab\u00a0Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB\/cJ mice.\u00a0\u00bb Neuropharmacology 112(Pt A): 198-209.<\/p>\n\n\n\n<p>&nbsp;David D. J., L. Tritschler, J. P. Guilloux, A. M. Gardier, C. Sanchez, R. Gaillard (2016). \u00ab\u00a0Pharmacological properties of vortioxetine and its pre-clinical consequences.\u00a0\u00bb Enc\u00e9phale. 42: 1S12<\/p>\n\n\n\n<p>&nbsp;Mendez-David, I., L. Tritschler, Z. E. Ali, M. H. Damiens, M. Pallardy, D. J. David, S. Kerdine-Romer and A. M. Gardier (2015). \u00ab\u00a0Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety\/depression.\u00a0\u00bb Neurosci Lett 597: 121-126.<\/p>\n\n\n\n<p>&nbsp;Nautiyal, K. M., L. Tritschler, S. E. Ahmari, D. J. David, A. M. Gardier and R. Hen (2016). \u00ab\u00a0A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors.\u00a0\u00bb Neuropsychopharmacology 41(12): 2941-2950.<\/p>\n\n\n\n<p>&nbsp;Tritschler, L., D. Felice, R. Colle, J. P. Guilloux, E. Corruble, A. M. Gardier and D. J. David (2014). \u00ab\u00a0Vortioxetine for the treatment of major depressive disorder.\u00a0\u00bb Expert Rev Clin Pharmacol: 1-15.<\/p>\n\n\n\n<p>&nbsp;Darcet, F., I. Mendez-David, L. Tritschler, A. M. Gardier, J. P. Guilloux and D. J. David (2014). \u00ab\u00a0Learning and memory impairments in a neuroendocrine mouse model of anxiety\/depression.\u00a0\u00bb Front Behav Neurosci 8: 136.<\/p>\n\n\n\n<p>&nbsp;Ansar, S., E. Chatzikonstantinou, R. Thiagarajah, L. Tritschler, M. Fatar, M. G. Hennerici and S. Meairs (2014). \u00ab\u00a0Pro-Inflammatory Mediators and Apoptosis Correlate to rt-PA Response in a Novel Mouse Model of Thromboembolic Stroke.\u00a0\u00bb PLoS One 9(1): e85849.<\/p>\n\n\n\n<p>&nbsp;Lehmann, O., H. Jeltsch, C. Lazarus, L. Tritschler, F. Bertrand and J. C. Cassel (2002). \u00ab\u00a0Combined 192 IgG-saporin and 5,7-dihydroxytryptamine lesions in the male rat brain: a neurochemical and behavioral study.\u00a0\u00bb Pharmacol Biochem Behav 72(4): 899-912.<\/p>\n\n\n\n<p>&nbsp;Tritschler, L., M. Saboureau, P. Pevet and B. Bothorel (2006). \u00ab\u00a0A functional subdivision of the circadian clock is revealed by differential effects of melatonin administration.\u00a0\u00bb Neurosci Lett 396(1): 73-76.<\/p>\n\n\n\n<p>&nbsp;Seminatore, C., J. Polentes, D. Ellman, N. Kozubenko, V. Itier, S. Tine, L. Tritschler, M. Brenot, E. Guidou, J. Blondeau, M. Lhuillier, A. Bugi, L. Aubry, P. Jendelova, E. Sykova, A. L. Perrier, B. Finsen and B. Onteniente (2010). \u00ab\u00a0The postischemic environment differentially impacts teratoma or tumor formation after transplantation of human embryonic stem cell-derived neural progenitors.\u00a0\u00bb Stroke 41(1): 153-159.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Assistant Professor PhD Tel: &nbsp;+33(0)1.80.00.63.36 Area of Research Neuropharmacology, Neurobiology of anxiety\/depression, Animal Models of Psychiatric Disorders. Expertise Dr. Tritschler continues now to work in vivo, he is studying the effects of the activation level of the hippocampus on the depressive-like behaviour as well as the changes induced by this stimulation on the hippocampus related&hellip; <br \/> <a class=\"read-more\" href=\"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/?page_id=152\">Lire la suite<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/152"}],"collection":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=152"}],"version-history":[{"count":7,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/152\/revisions"}],"predecessor-version":[{"id":623,"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=\/wp\/v2\/pages\/152\/revisions\/623"}],"wp:attachment":[{"href":"http:\/\/www.neuropharmacologie.universite-paris-saclay.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}